| Literature DB >> 15006396 |
Tooru Kimura1, Daisuke Shuto, Soko Kasai, Ping Liu, Koushi Hidaka, Takashi Hamada, Yoshio Hayashi, Chinatsu Hattori, Masashi Asai, Shinobu Kitazume, Takaomi C Saido, Shoichi Ishiura, Yoshiaki Kiso.
Abstract
Recently, we reported a novel substrate-based octapeptide BACE1 inhibitor KMI-008 containing hydroxymethylcarbonyl (HMC) isostere as a transition-state mimic. Using KMI-008 as a lead compound, a small-sized and highly potent BACE1 inhibitor KMI-370 (IC(50)=3.4 nM) was designed and synthesized.Entities:
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Year: 2004 PMID： 15006396 DOI： 10.1016/j.bmcl.2003.12.088
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823