| Literature DB >> 15006393 |
Charles Q Meng1, X Sharon Zheng, Liming Ni, Zhihong Ye, Jacob E Simpson, Kimberly J Worsencroft, Martha R Hotema, M David Weingarten, Jason W Skudlarek, Joshua M Gilmore, Lee K Hoong, Russell R Hill, Elaine M Marino, Ki-Ling Suen, Charles Kunsch, Martin A Wasserman, James A Sikorski.
Abstract
Novel chalcone derivatives have been discovered as potent inhibitors of TNF-alpha-induced VCAM-1 expression. Thienyl or benzothienyl substitution at the meta-position of ring B helps boost potency while large substitution at the para-position on ring B is detrimental. Various substitutions are tolerated on ring A. A lipophilicity-potency relationship has been observed in several sub-series of compounds.Entities:
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Year: 2004 PMID： 15006393 DOI： 10.1016/j.bmcl.2004.01.021
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823