| Literature DB >> 15006379 |
Robert B Perni1, Janos Pitlik, Shawn D Britt, John J Court, Lawrence F Courtney, David D Deininger, Luc J Farmer, Cynthia A Gates, Scott L Harbeson, Rhonda B Levin, Chao Lin, Kai Lin, Young-Choon Moon, Yu-Ping Luong, Ethan T O'Malley, B Govinda Rao, John A Thomson, Roger D Tung, John H Van Drie, Yunyi Wei.
Abstract
The alpha-ketoamide warhead (e.g., 15) was found to be a practical replacement for aliphatic aldehydes in a series of HCV NS3.4A protease inhibitors. Structure-activity relationships and prime side optimization are discussed.Entities:
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Year: 2004 PMID： 15006379 DOI： 10.1016/j.bmcl.2004.01.022
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823