| Literature DB >> 15006378 |
Christopher J Arnusch1, Sabine André, Paola Valentini, Martin Lensch, Roland Russwurm, Hans-Christian Siebert, Marcel J E Fischer, Hans-Joachim Gabius, Roland J Pieters.
Abstract
A library of pentapeptides containing the sequence -Y-X-Y- based on rational design was screened with six different lectins. Sequences were identified that modulate galectin binding to its natural carbohydrate ligand. SPR showed inhibition values 2-3 times stronger than galactose and NMR studies suggested real carbohydrate mimicry.Entities:
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Year: 2004 PMID： 15006378 DOI： 10.1016/j.bmcl.2004.01.029
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823