| Literature DB >> 15006376 |
Lee D Jennings1, Ken W Foreman, Thomas S Rush, Desiree H H Tsao, Lidia Mosyak, Yuanhong Li, Mohani N Sukhdeo, Weidong Ding, Elizabeth G Dushin, Cynthia Hess Kenny, Soraya L Moghazeh, Peter J Petersen, Alexey V Ruzin, Margareta Tuckman, Alan G Sutherland.
Abstract
The binding of FtsZ to ZipA is a potential target for antibacterial therapy. Based on a small molecule inhibitor of the ZipA-FtsZ interaction, a parallel synthesis of small molecules was initiated which targeted a key region of ZipA involved in FtsZ binding. The X-ray crystal structure of one of these molecules complexed with ZipA was solved. The structure revealed an unexpected binding mode, facilitated by desolvation of a loosely bound surface water.Entities:
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Year: 2004 PMID： 15006376 DOI： 10.1016/j.bmcl.2004.01.028
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823