Literature DB >> 15006374

Estrogen receptor ligands. Part 1: The discovery of flavanoids with subtype selectivity.

Helen Y Chen1, Kevin D Dykstra, Elizabeth T Birzin, Katalin Frisch, Wanda Chan, Yi T Yang, Ralph T Mosley, Frank DiNinno, Susan P Rohrer, James M Schaeffer, Milton L Hammond.   

Abstract

A class of flavanoids exhibiting a high degree of selectivity for ERalpha over ERbeta has been discovered. The most active analogue 6 was found to be 66-fold ERalpha-selective and demonstrated uterine estradiol antagonism.

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Year:  2004        PMID： 15006374     DOI： 10.1016/j.bmcl.2004.01.031

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Selective estrogen receptor modulators regulate stromal proliferation in human benign prostatic hyperplasia by multiple beneficial mechanisms--action of two new agents.

Authors:  Rajeev Kumar; Vikas Verma; Amit Sarswat; J P Maikhuri; Ashish Jain; Rajeev K Jain; V L Sharma; Diwakar Dalela; Gopal Gupta
Journal:  Invest New Drugs       Date:  2010-12-23       Impact factor: 3.850

2.  Synthesis and Evaluation of Estradiol Derivatives as Anti-Breast Cancer Agents.

Authors:  John S Cooperwood; Jesse Edwards; Musiliyu Musa; Devora Simmons; Abdul D Mian; Kwon-Kyun Park; Zhongliang Wan
Journal:  Lett Drug Des Discov       Date:  2010-07-01       Impact factor: 1.150

3.  Prediction of binding affinity for estrogen receptor alpha modulators using statistical learning approaches.

Authors:  Yonghua Wang; Yan Li; Jun Ding; Yuan Wang; Yaqing Chang
Journal:  Mol Divers       Date:  2008-07-26       Impact factor: 2.943

4.  Identification of xenoestrogens in food additives by an integrated in silico and in vitro approach.

Authors:  Alessio Amadasi; Andrea Mozzarelli; Clara Meda; Adriana Maggi; Pietro Cozzini
Journal:  Chem Res Toxicol       Date:  2009-01       Impact factor: 3.739

5.  Rationally modified estrogen receptor protein as a bio-recognition element for the detection of EDC pollutants: strategies and opportunities.

Authors:  Mattia Pedotti; Valentina Elisabetta Viviana Ferrero; Teresa Lettieri; Pascal Colpo; Stephane Follonier; Luigi Calzolai; Luca Varani
Journal:  Int J Environ Res Public Health       Date:  2015-02-27       Impact factor: 3.390

6.  Synergistic Action of Flavonoids, Baicalein, and Daidzein in Estrogenic and Neuroprotective Effects: A Development of Potential Health Products and Therapeutic Drugs against Alzheimer's Disease.

Authors:  Roy C Y Choi; Judy T T Zhu; Amanda W Y Yung; Pinky S C Lee; Sherry L Xu; Ava J Y Guo; Kevin Y Zhu; Tina T X Dong; Karl W K Tsim
Journal:  Evid Based Complement Alternat Med       Date:  2013-08-24       Impact factor: 2.629

7.  Design and synthesis of chiral and regenerable [2.2]paracyclophane-based NAD(P)H models and application in biomimetic reduction of flavonoids.

Authors:  Zhou-Hao Zhu; Yi-Xuan Ding; Bo Wu; Yong-Gui Zhou
Journal:  Chem Sci       Date:  2020-09-10       Impact factor: 9.825

Review 8.  Versatility or promiscuity: the estrogen receptors, control of ligand selectivity and an update on subtype selective ligands.

Authors:  Hui Wen Ng; Roger Perkins; Weida Tong; Huixiao Hong
Journal:  Int J Environ Res Public Health       Date:  2014-08-26       Impact factor: 3.390
  8 in total

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