Literature DB >> 15004007

Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction.

Bisei Ohkawara1, Kyoko Shirakabe, Junko Hyodo-Miura, Ritsuko Matsuo, Naoto Ueno, Kunihiro Matsumoto, Hiroshi Shibuya.   

Abstract

Transforming growth factor (TGF)-beta-activated kinase 1 (TAK1) and Nemo-like kinase (NLK) function in Xenopus, Drosophila, and Caenorhabditis elegans development. Here we report that serine phosphorylation of STAT3 induced by TAK1-NLK cascade is essential fo TGF-beta-mediated mesoderm induction in Xenopus embryo. Depletion of TAK1, NLK, or STAT3 blocks TGF-beta-mediated mesoderm induction. Coexpression of NLK and STAT3 induces mesoderm by a mechanism that requires serine phosphorylation of STAT3. Activin activates NLK, which in turn directly phosphorylates STAT3. Moreover, depletion of either TAK1 or NLK inhibits endogenous serine phosphorylation of STAT3. These results provide the first evidence that TAK1-NLK-STAT3 cascade participates in TGF-beta-mediated mesoderm induction.

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Year:  2004        PMID： 15004007      PMCID： PMC359392          DOI： 10.1101/gad.1166904

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  29 in total

Review 1.  Xwnt11 and the regulation of gastrulation in Xenopus.

Authors:  J C Smith; F L Conlon; Y Saka; M Tada
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2000-07-29       Impact factor: 6.237

Review 2.  Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.

Authors:  T Hirano; K Ishihara; M Hibi
Journal:  Oncogene       Date:  2000-05-15       Impact factor: 9.867

Review 3.  Cytokine signaling in 2002: new surprises in the Jak/Stat pathway.

Authors:  John J O'Shea; Massimo Gadina; Robert D Schreiber
Journal:  Cell       Date:  2002-04       Impact factor: 41.582

Review 4.  Convergent extension: the molecular control of polarized cell movement during embryonic development.

Authors:  John B Wallingford; Scott E Fraser; Richard M Harland
Journal:  Dev Cell       Date:  2002-06       Impact factor: 12.270

5.  Stat3 as an oncogene.

Authors:  J F Bromberg; M H Wrzeszczynska; G Devgan; Y Zhao; R G Pestell; C Albanese; J E Darnell
Journal:  Cell       Date:  1999-08-06       Impact factor: 41.582

6.  The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF.

Authors:  T Ishitani; J Ninomiya-Tsuji; S Nagai; M Nishita; M Meneghini; N Barker; M Waterman; B Bowerman; H Clevers; H Shibuya; K Matsumoto
Journal:  Nature       Date:  1999-06-24       Impact factor: 49.962

Review 7.  How cells read TGF-beta signals.

Authors:  J Massagué
Journal:  Nat Rev Mol Cell Biol       Date:  2000-12       Impact factor: 94.444

Review 8.  Serine phosphorylation of STATs.

Authors:  T Decker; P Kovarik
Journal:  Oncogene       Date:  2000-05-15       Impact factor: 9.867

9.  Involvement of NLK and Sox11 in neural induction in Xenopus development.

Authors:  Junko Hyodo-Miura; Seiichi Urushiyama; Shin-ichi Nagai; Michiru Nishita; Naoto Ueno; Hiroshi Shibuya
Journal:  Genes Cells       Date:  2002-05       Impact factor: 1.891

10.  Endodermal Nodal-related signals and mesoderm induction in Xenopus.

Authors:  E Agius; M Oelgeschläger; O Wessely; C Kemp; E M De Robertis
Journal:  Development       Date:  2000-03       Impact factor: 6.868
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  47 in total

1.  Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning.

Authors:  Wan-Tae Kim; Hyunjoon Kim; Vladimir L Katanaev; Seung Joon Lee; Tohru Ishitani; Boksik Cha; Jin-Kwan Han; Eek-Hoon Jho
Journal:  EMBO J       Date:  2012-07-06       Impact factor: 11.598

2.  xBtg-x regulates Wnt/beta-Catenin signaling during early Xenopus development.

Authors:  Oliver Wessely; James I Kim; Uyen Tran; Luis Fuentealba; E M De Robertis
Journal:  Dev Biol       Date:  2005-07-01       Impact factor: 3.582

3.  β-Catenin-related protein WRM-1 is a multifunctional regulatory subunit of the LIT-1 MAPK complex.

Authors:  Xiao-Dong Yang; Tejas R Karhadkar; Jessica Medina; Scott M Robertson; Rueyling Lin
Journal:  Proc Natl Acad Sci U S A       Date:  2014-12-29       Impact factor: 11.205

4.  NLK positively regulates Wnt/β-catenin signalling by phosphorylating LEF1 in neural progenitor cells.

Authors:  Satoshi Ota; Shizuka Ishitani; Nobuyuki Shimizu; Kunihiro Matsumoto; Motoyuki Itoh; Tohru Ishitani
Journal:  EMBO J       Date:  2012-02-28       Impact factor: 11.598

5.  NLK is a key regulator of proliferation and migration in gallbladder carcinoma cells.

Authors:  Zhujun Tan; Maolan Li; Wenguang Wu; Lin Zhang; Qichen Ding; Xiangsong Wu; Jiasheng Mu; Yingbin Liu
Journal:  Mol Cell Biochem       Date:  2012-06-24       Impact factor: 3.396

6.  STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation.

Authors:  Hirotada Kojima; Takanori Sasaki; Tohru Ishitani; Shun-ichiro Iemura; Hong Zhao; Shuhei Kaneko; Hiroyuki Kunimoto; Tohru Natsume; Kunihiro Matsumoto; Koichi Nakajima
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-11       Impact factor: 11.205

7.  Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex.

Authors:  Tohru Ishitani; Tomoko Hirao; Maho Suzuki; Miho Isoda; Shizuka Ishitani; Kenichi Harigaya; Motoo Kitagawa; Kunihiro Matsumoto; Motoyuki Itoh
Journal:  Nat Cell Biol       Date:  2010-01-31       Impact factor: 28.824

8.  Bortezomib inhibits STAT5-dependent degradation of LEF-1, inducing granulocytic differentiation in congenital neutropenia CD34(+) cells.

Authors:  Kshama Gupta; Inna Kuznetsova; Olga Klimenkova; Maksim Klimiankou; Johann Meyer; Malcolm A S Moore; Cornelia Zeidler; Karl Welte; Julia Skokowa
Journal:  Blood       Date:  2014-01-06       Impact factor: 22.113

9.  Nemo regulates cell dynamics and represses the expression of miple, a midkine/pleiotrophin cytokine, during ommatidial rotation.

Authors:  Verónica Muñoz-Soriano; Carlos Ruiz; Manuel Pérez-Alonso; Marek Mlodzik; Nuria Paricio
Journal:  Dev Biol       Date:  2013-02-18       Impact factor: 3.582

10.  Nemo-like kinase, an essential effector of anterior formation, functions downstream of p38 mitogen-activated protein kinase.

Authors:  Eriko Ohnishi; Toshiyasu Goto; Atsushi Sato; Mi-Sun Kim; Shun-Ichiro Iemura; Tohru Ishitani; Tohru Natsume; Junji Ohnishi; Hiroshi Shibuya
Journal:  Mol Cell Biol       Date:  2009-11-23       Impact factor: 4.272
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