Literature DB >> 15003642

Sporozoite and liver stage antigen Plasmodium falciparum peptides bind specifically to human hepatocytes.

Alvaro Puentes1, Javier García, Ricardo Vera, Ramsés López, Jorge Suarez, Luis Rodríguez, Hernando Curtidor, Marisol Ocampo, Diana Tovar, Martha Forero, Adriana Bermudez, Jimena Cortes, Mauricio Urquiza, Manuel E Patarroyo.   

Abstract

Sporozoite and Liver Stage Antigen (SALSA) sequence synthetic peptides were used in HepG2 cell binding assays to identify regions involved in parasite invasion. SALSA 20608 ( 21IWASEKKDEKEASEQGEESHY40) and 20611 ( 64KKDDGTDKVQEKVLEKSPKY83) peptides were determined as having high binding activity in HepG2 cell assays, some of them were located in immunogenic regions. Immune-fluorescence antibody test with 24276 (20608 peptide analogue, CGIWSSMKMDEKMAAMQGEESHCG) showed sporozoite and merozoite reactivity. This data suggests SALSA high activity binding peptides' (HABPs) possible role in hepatic cell invasion and merozoite invasion of erythrocytes.

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Year:  2004        PMID： 15003642     DOI： 10.1016/j.vaccine.2003.09.029

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  6 in total

1.  Mycobacterium tuberculosis Rv2536 protein implicated in specific binding to human cell lines.

Authors:  Javier García; Alvaro Puentes; Luis Rodríguez; Marisol Ocampo; Hernando Curtidor; Ricardo Vera; Ramses Lopez; John Valbuena; Jimena Cortes; Magnolia Vanegas; Carlos Barrero; Manuel A Patarroyo; Mauricio Urquiza; Manuel E Patarroyo
Journal:  Protein Sci       Date:  2005-09       Impact factor: 6.725

Review 2.  Developmental biology of sporozoite-host interactions in Plasmodium falciparum malaria: implications for vaccine design.

Authors:  Javier E Garcia; Alvaro Puentes; Manuel E Patarroyo
Journal:  Clin Microbiol Rev       Date:  2006-10       Impact factor: 26.132

3.  Identifying putative Mycobacterium tuberculosis Rv2004c protein sequences that bind specifically to U937 macrophages and A549 epithelial cells.

Authors:  Martha Forero; Alvaro Puentes; Jimena Cortés; Fabio Castillo; Ricardo Vera; Luis E Rodríguez; John Valbuena; Marisol Ocampo; Hernando Curtidor; Jaiver Rosas; Javier García; Gloria Barrera; Rosalba Alfonso; Manuel A Patarroyo; Manuel E Patarroyo
Journal:  Protein Sci       Date:  2005-09-30       Impact factor: 6.725

4.  Cloning of a novel Babesia equi gene encoding a 158-kilodalton protein useful for serological diagnosis.

Authors:  Haruyuki Hirata; Naoaki Yokoyama; Xuenan Xuan; Kozo Fujisaki; Naoyoshi Suzuki; Ikuo Igarashi
Journal:  Clin Diagn Lab Immunol       Date:  2005-02

5.  Defining the erythrocyte binding domains of Plasmodium vivax tryptophan rich antigen 33.5.

Authors:  Hema Bora; Rupesh Kumar Tyagi; Yagya Dutta Sharma
Journal:  PLoS One       Date:  2013-04-25       Impact factor: 3.240

6.  Proteomic profiling of Plasmodium sporozoite maturation identifies new proteins essential for parasite development and infectivity.

Authors:  Edwin Lasonder; Chris J Janse; Geert-Jan van Gemert; Gunnar R Mair; Adriaan M W Vermunt; Bruno G Douradinha; Vera van Noort; Martijn A Huynen; Adrian J F Luty; Hans Kroeze; Shahid M Khan; Robert W Sauerwein; Andrew P Waters; Matthias Mann; Hendrik G Stunnenberg
Journal:  PLoS Pathog       Date:  2008-10-31       Impact factor: 6.823
  6 in total

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