Literature DB >> 15003621

Cdc42: new roads to travel.

Richard A Cerione1.   

Abstract

The roles of Cdc42 in stimulating changes in the actin cytoskeleton and in the establishment of cell polarity have been known for some time. However, evidence implicating Cdc42 in intracellular trafficking and in the regulation of cell growth have continued to surface. Recently, exciting developments have highlighted how Cdc42 might participate in these cellular functions by regulating the processing of the EGF receptor. Here, I discuss these findings within the broader context of how Cdc42 serves as a multifaceted signaling switch that links trafficking events to the control of cell growth.

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Year:  2004        PMID： 15003621     DOI： 10.1016/j.tcb.2004.01.008

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  60 in total

1.  A quantitative fluorometric approach for measuring the interaction of RhoGDI with membranes and Rho GTPases.

Authors:  Jared Johnson; Richard A Cerione; Jon W Erickson
Journal:  Methods Mol Biol       Date:  2012

2.  Cdc42 mediates nucleus movement and MTOC polarization in Swiss 3T3 fibroblasts under mechanical shear stress.

Authors:  Jerry S H Lee; Melissa I Chang; Yiider Tseng; Denis Wirtz
Journal:  Mol Biol Cell       Date:  2004-11-17       Impact factor: 4.138

3.  Compartmentalized Ras proteins transform NIH 3T3 cells with different efficiencies.

Authors:  Chiang-Min Cheng; Huiling Li; Stéphane Gasman; Jian Huang; Rachel Schiff; Eric C Chang
Journal:  Mol Cell Biol       Date:  2010-12-28       Impact factor: 4.272

4.  A minimal Rac activation domain in the unconventional guanine nucleotide exchange factor Dock180.

Authors:  Xin Wu; Sekar Ramachandran; Miao-Chong J Lin; Richard A Cerione; Jon W Erickson
Journal:  Biochemistry       Date:  2011-01-20       Impact factor: 3.162

5.  Intersectin-1L nucleotide exchange factor regulates secretory granule exocytosis by activating Cdc42.

Authors:  Magali Malacombe; Mara Ceridono; Valérie Calco; Sylvette Chasserot-Golaz; Peter S McPherson; Marie-France Bader; Stéphane Gasman
Journal:  EMBO J       Date:  2006-07-27       Impact factor: 11.598

6.  Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.

Authors:  Lei Wang; Linda Yang; Marcella Debidda; David Witte; Yi Zheng
Journal:  Proc Natl Acad Sci U S A       Date:  2007-01-16       Impact factor: 11.205

7.  Transport of influenza virus neuraminidase (NA) to host cell surface is regulated by ARHGAP21 and Cdc42 proteins.

Authors:  Song Wang; Hua Li; Yuhai Chen; Haitao Wei; George F Gao; Hongqiang Liu; Shile Huang; Ji-Long Chen
Journal:  J Biol Chem       Date:  2012-02-08       Impact factor: 5.157

8.  Expansion of signal transduction by G proteins. The second 15 years or so: from 3 to 16 alpha subunits plus betagamma dimers.

Authors:  Lutz Birnbaumer
Journal:  Biochim Biophys Acta       Date:  2006-12-15

9.  Molecular characterisation of the small GTPase CDC42 in the ectomycorrhizal fungus Tuber borchii Vittad.

Authors:  M Menotta; A Amicucci; G Basili; F Rivero; E Polidori; D Sisti; V Stocchi
Journal:  Protoplasma       Date:  2007-08-30       Impact factor: 3.356

10.  Tyrosine phosphorylation of Dbl regulates GTPase signaling.

Authors:  Meghana Gupta; Xiaojun Qi; Varsha Thakur; Danny Manor
Journal:  J Biol Chem       Date:  2014-04-28       Impact factor: 5.157
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