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Literature DB >> 1500347

Mersacidin, a new antibiotic from Bacillus. Fermentation, isolation, purification and chemical characterization.

S Chatterjee¹, S Chatterjee¹, S J Lad, M S Phansalkar, R H Rupp, B N Ganguli, H W Fehlhaber, H Kogler.

Abstract

Mersacidin (1) is a new peptide antibiotic containing beta-methyllanthionine. It is classified as a member of the proposed lantibiotic group of antibiotics, and is produced by a species of Bacillus. Mersacidin has a molecular weight of 1,824 (C80H120N20O21S4). The antibiotic is active against Gram-positive organisms including methicillin-resistant Staphylococcus aureus, but has no activity against Gram-negative bacteria or fungi.

Entities: Chemical Species

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Year: 1992 PMID： 1500347 DOI： 10.7164/antibiotics.45.832

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

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Cited

39 in total

1. Biosynthesis of the lantibiotic mersacidin: organization of a type B lantibiotic gene cluster.

Authors: K Altena; A Guder; C Cramer; G Bierbaum
Journal: Appl Environ Microbiol Date: 2000-06 Impact factor: 4.792

2. Role of the single regulator MrsR1 and the two-component system MrsR2/K2 in the regulation of mersacidin production and immunity.

Authors: André Guder; Tim Schmitter; Imke Wiedemann; Hans-Georg Sahl; Gabriele Bierbaum
Journal: Appl Environ Microbiol Date: 2002-01 Impact factor: 4.792

3. The flavoprotein MrsD catalyzes the oxidative decarboxylation reaction involved in formation of the peptidoglycan biosynthesis inhibitor mersacidin.

Authors: Florian Majer; Dietmar G Schmid; Karsten Altena; Gabriele Bierbaum; Thomas Kupke
Journal: J Bacteriol Date: 2002-03 Impact factor: 3.490

Review 4. Peptide antimicrobial agents.

Authors: Håvard Jenssen; Pamela Hamill; Robert E W Hancock
Journal: Clin Microbiol Rev Date: 2006-07 Impact factor: 26.132

Mersacidin, a new antibiotic from Bacillus. Fermentation, isolation, purification and chemical characterization.

1. Biosynthesis of the lantibiotic mersacidin: organization of a type B lantibiotic gene cluster.

2. Role of the single regulator MrsR1 and the two-component system MrsR2/K2 in the regulation of mersacidin production and immunity.

3. The flavoprotein MrsD catalyzes the oxidative decarboxylation reaction involved in formation of the peptidoglycan biosynthesis inhibitor mersacidin.

Review 4. Peptide antimicrobial agents.

5. The lantibiotic mersacidin is an autoinducing peptide.

6. Investigating the importance of charged residues in lantibiotics.

7. Construction of an expression system for site-directed mutagenesis of the lantibiotic mersacidin.

8. Bacillus DNA in fossil bees: an ancient symbiosis?

9. Dissecting structural and functional diversity of the lantibiotic mersacidin.

10. Insights into the mode of action of the two-peptide lantibiotic haloduracin.