| Literature DB >> 15003360 |
J V Seale1, D S Jessop, M S Harbuz.
Abstract
Endomorphin 1 (EM-1) and EM-2 have been widely reported in the cells of the central nervous system (CNS) but limited research has been done regarding their distribution in the peripheral system. The occurrence of EM-1 and -2 in the spleen as measured by RIA and their ability to mediate immune function imply a role for EMs in this area. The current study examines the localization of EM-1 and -2 in the immune cells of the spleen of male and female rats via an immunohistochemical procedure. In both genders, EM-1 and -2 immunoreactive staining was predominantly present in macrophages and B cells with minimal EM immunoreactive staining in T cells. This is the first evidence of a differential distribution of EM-1 and -2 in cells of the immune system.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15003360 DOI： 10.1016/j.peptides.2003.11.016
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750