Literature DB >> 15003359

The C-terminus of murine S100A9 inhibits hyperalgesia and edema induced by jararhagin.

Camila Squarzoni Dale1, Luis Roberto de Camargo Gonçalves, Luiz Juliano, Maria Aparecida Juliano, Ana Maria Moura da Silva, Renata Giorgi.   

Abstract

The effect of a synthetic peptide (H92-G110) identical to the C-terminus of murine S100A9 (mS100A9p) was investigated on hyperalgesia and edema induced by either jararhagin or papain in the rat paw. mS100A9p not only reverted hyperalgesia and edema induced by jararhagin, but also the highest concentration induced antinociception. Hemorrhage induced by jararhagin and its hydrolytic activity were inhibited by mS100A9p. These data suggest that mS100A9p might block jararhagin-induced hyperalgesia and edema by inhibiting jararhagin catalytic activity, since papain-induced hyperalgesia and edema were not inhibited by mS100A9p.

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Year:  2004        PMID： 15003359     DOI： 10.1016/j.peptides.2003.12.008

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  5 in total

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2.  The C-terminus of murine S100A9 protein inhibits hyperalgesia induced by the agonist peptide of protease-activated receptor 2 (PAR2).

Authors:  C S Dale; N Cenac; L R G Britto; M A Juliano; L Juliano; N Vergnolle; R Giorgi
Journal:  Br J Pharmacol       Date:  2006-09-11       Impact factor: 8.739

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Journal:  Toxins (Basel)       Date:  2020-02-02       Impact factor: 4.546

5.  Modulation of Adhesion Molecules Expression by Different Metalloproteases Isolated from Bothrops Snakes.

Authors:  Bianca C Zychar; Patrícia B Clissa; Eneas Carvalho; Adilson S Alves; Cristiani Baldo; Eliana L Faquim-Mauro; Luís Roberto C Gonçalves
Journal:  Toxins (Basel)       Date:  2021-11-15       Impact factor: 4.546
  5 in total

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