| Literature DB >> 15003289 |
Chiaki Yokota1, Tomohito Kaji, Yuji Kuge, Hiroyasu Inoue, Nagara Tamaki, Kazuo Minematsu.
Abstract
Substantial increases in cyclooxygenase-2 (COX-2) mRNA and protein levels were demonstrated in the peri-infarct and focal ischemic areas after 3-24 and 12-24 h, respectively, in rats. In the ischemic core, significant increases in COX-2 mRNA followed 6 h of ischemia, though the peak level was about one-third of that in the peri-infarct area. Increases in COX-2 protein in the ischemic core were not observed during ischemic periods. Diffuse, neuronal COX-2 staining was found in peri-infarct areas as well as in discrete, immunoreactive neurons in the ischemic core. Robust increases in prostaglandin E2 levels in the peri-infarct area were demonstrated following 24 h of ischemia. Prostaglandin production as well as COX-2 expression in ischemic tissues depended on the degree and duration of the reduction in cerebral blood flow.Entities:
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Year: 2004 PMID： 15003289 DOI： 10.1016/j.neulet.2003.12.109
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046