Literature DB >> 1500191

Immune response to outer membrane antigens of Moraxella catarrhalis in children with otitis media.

H Faden1, J Hong, T Murphy.   

Abstract

The systemic and local antibody responses to homologous strains of Moraxella catarrhalis were investigated in 14 children with otitis media. A total of 8 children (57%) demonstrated a rise in serum antibody of the immunoglobulin G (IgG) (5 of 14), IgM (5 of 14), or IgA (6 of 14) classes of immunoglobulin to outer membrane antigens. Local antibody consisted of IgG (100%), IgM (29%), and IgA (71%). The IgG and IgA specific antibody present in middle-ear effusions appeared to represent local production rather than passive diffusion from the systemic circulation. These data suggest that young children develop an antibody response to M. catarrhalis in the middle ear during otitis media but fail to develop systemic antibody in a uniform manner.

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Year:  1992        PMID： 1500191      PMCID： PMC257395          DOI： 10.1128/iai.60.9.3824-3829.1992

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  35 in total

1.  Nasopharyngeal flora in the first three years of life in normal and otitis-prone children.

Authors:  H Faden; M J Waz; J M Bernstein; L Brodsky; J Stanievich; P L Ogra
Journal:  Ann Otol Rhinol Laryngol       Date:  1991-08       Impact factor: 1.547

2.  Identification of a 16,600-dalton outer membrane protein on nontypeable Haemophilus influenzae as a target for human serum bactericidal antibody.

Authors:  T F Murphy; L C Bartos; P A Rice; M B Nelson; K C Dudas; M A Apicella
Journal:  J Clin Invest       Date:  1986-10       Impact factor: 14.808

3.  Cephalexin monohydrate suspension. Treatment of otitis media.

Authors:  S E McLinn; J F Daly; J E Jones
Journal:  JAMA       Date:  1975-10-13       Impact factor: 56.272

4.  Antibody response to P-protein in patients with Branhamella catarrhalis infections.

Authors:  D S Chi; A Verghese; C Moore; F Hamati; S L Berk
Journal:  Am J Med       Date:  1990-05-14       Impact factor: 4.965

5.  Surface-exposed and antigenically conserved determinants of outer membrane proteins of Branhamella catarrhalis.

Authors:  T F Murphy; L C Bartos
Journal:  Infect Immun       Date:  1989-10       Impact factor: 3.441

6.  Changes in nasopharyngeal flora during otitis media of childhood.

Authors:  H Faden; J Stanievich; L Brodsky; J Bernstein; P L Ogra
Journal:  Pediatr Infect Dis J       Date:  1990-09       Impact factor: 2.129

7.  Branhamella catarrhalis: antigenic determinants and the development of the IgG subclass response in childhood.

Authors:  D Goldblatt; M W Turner; R J Levinsky
Journal:  J Infect Dis       Date:  1990-11       Impact factor: 5.226

8.  Pneumococcal antibodies and complement during and after periods of recurrent otitis.

Authors:  K Prellner; O Kalm; F K Pedersen
Journal:  Int J Pediatr Otorhinolaryngol       Date:  1984-03       Impact factor: 1.675

9.  Emergence of beta-lactamase-producing strains of Branhamella catarrhalis as important agents of acute otitis media.

Authors:  P A Shurin; C D Marchant; C H Kim; G F Van Hare; C E Johnson; M A Tutihasi; L J Knapp
Journal:  Pediatr Infect Dis       Date:  1983 Jan-Feb

10.  Preliminary serologic evidence for a pathogenic role of Branhamella catarrhalis.

Authors:  M Leinonen; J Luotonen; E Herva; K Valkonen; P H Mäkelä
Journal:  J Infect Dis       Date:  1981-12       Impact factor: 5.226
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  26 in total

1.  Multiplex PCR assay that identifies the major lipooligosaccharide serotype expressed by Moraxella catarrhalis clinical isolates.

Authors:  Katie J Edwards; Johanna M Schwingel; Anup K Datta; Anthony A Campagnari
Journal:  J Clin Microbiol       Date:  2005-12       Impact factor: 5.948

2.  Identification of two late acyltransferase genes responsible for lipid A biosynthesis in Moraxella catarrhalis.

Authors:  Song Gao; Daxin Peng; Wenhong Zhang; Artur Muszyński; Russell W Carlson; Xin-Xing Gu
Journal:  FEBS J       Date:  2008-09-13       Impact factor: 5.542

3.  Serum antibody response to outer membrane proteins of Moraxella (Branhamella) catarrhalis in patients with bronchopulmonary infection.

Authors:  J J Christensen; N Q Hansen; B Bruun
Journal:  Clin Diagn Lab Immunol       Date:  1996-11

4.  Characterization of the Moraxella catarrhalis opa-like protein, OlpA, reveals a phylogenetically conserved family of outer membrane proteins.

Authors:  Michael J Brooks; Cassie A Laurence; Eric J Hansen; Scott D Gray-Owen
Journal:  J Bacteriol       Date:  2006-10-13       Impact factor: 3.490

5.  Biological and immunological characteristics of lipooligosaccharide-based conjugate vaccines for serotype C Moraxella catarrhalis.

Authors:  Shengqing Yu; Xin-Xing Gu
Journal:  Infect Immun       Date:  2007-03-19       Impact factor: 3.441

6.  Adenovirus serotype 1 does not act synergistically with Moraxella (Branhamella) catarrhalis to induce otitis media in the chinchilla.

Authors:  L O Bakaletz; D M Murwin; J M Billy
Journal:  Infect Immun       Date:  1995-10       Impact factor: 3.441

7.  A major outer membrane protein of Moraxella catarrhalis is a target for antibodies that enhance pulmonary clearance of the pathogen in an animal model.

Authors:  M E Helminen; I Maciver; J L Latimer; L D Cope; G H McCracken; E J Hansen
Journal:  Infect Immun       Date:  1993-05       Impact factor: 3.441

8.  Lack of serotype-specific antibody response to lipopolysaccharide antigens of Moraxella catarrhalis during lower respiratory tract infection.

Authors:  M Rahman; T Holme; I Jönsson; A Krook
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1995-04       Impact factor: 3.267

9.  Human immune response against outer membrane proteins of Moraxella (Branhamella) catarrhalis determined by immunoblotting and enzyme immunoassay.

Authors:  M E Helminen; R Beach; I Maciver; G Jarosik; E J Hansen; M Leinonen
Journal:  Clin Diagn Lab Immunol       Date:  1995-01

10.  Serum antibodies to outer membrane proteins (OMPs) of Moraxella (Branhamella) catarrhalis in patients with bronchiectasis: identification of OMP B1 as an important antigen.

Authors:  S Sethi; S L Hill; T F Murphy
Journal:  Infect Immun       Date:  1995-04       Impact factor: 3.441
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