Literature DB >> 15001778

Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors.

Zhiguo Nie1, Paul Schweitzer, Amanda J Roberts, Samuel G Madamba, Scott D Moore, George Robert Siggins.   

Abstract

The central amygdala (CeA) plays a role in the relationship among stress, corticotropin-releasing factor (CRF), and alcohol abuse. In whole-cell recordings, both CRF and ethanol enhanced gamma-aminobutyric acid-mediated (GABAergic) neurotransmission in CeA neurons from wild-type and CRF2 receptor knockout mice, but not CRF1 receptor knockout mice. CRF1 (but not CRF2) receptor antagonists blocked both CRF and ethanol effects in wild-type mice. These data indicate that CRF1 receptors mediate ethanol enhancement of GABAergic synaptic transmission in the CeA, and they suggest a cellular mechanism underlying involvement of CRF in ethanol's behavioral and motivational effects.

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Year:  2004        PMID： 15001778     DOI： 10.1126/science.1092550

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  137 in total

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3.  Receptor subtype-dependent galanin actions on gamma-aminobutyric acidergic neurotransmission and ethanol responses in the central amygdala.

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4.  Enhanced dendritic availability of μ-opioid receptors in inhibitory neurons of the extended amygdala in mice deficient in the corticotropin-releasing factor-1 receptor.

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6.  Involvement of non-NMDA glutamate receptors in central amygdala in synaptic actions of ethanol and ethanol-induced reward behavior.

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7.  Enhanced GABAergic transmission in the central nucleus of the amygdala of genetically selected Marchigian Sardinian rats: alcohol and CRF effects.

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8.  Alcohol attenuates amygdala-frontal connectivity during processing social signals in heavy social drinkers: a preliminary pharmaco-fMRI study.

Authors:  Stephanie M Gorka; Daniel A Fitzgerald; Andrea C King; K Luan Phan
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9.  κ-Opioid receptors in the central amygdala regulate ethanol actions at presynaptic GABAergic sites.

Authors:  Maenghee Kang-Park; Brigitte L Kieffer; Amanda J Roberts; George R Siggins; Scott D Moore
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10.  Mu-opioid receptors selectively regulate basal inhibitory transmission in the central amygdala: lack of ethanol interactions.

Authors:  Maeng-Hee Kang-Park; Brigitte L Kieffer; Amanda J Roberts; Marisa Roberto; Samuel G Madamba; George Robert Siggins; Scott D Moore
Journal:  J Pharmacol Exp Ther       Date:  2008-10-14       Impact factor: 4.030
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