AIMS AND METHODS: Alterations in cholesterol and phospholipid contents as well as fluidity and lipid peroxidation in erythrocyte membranes from chronic alcoholic humans were investigated. RESULTS: While an increase in cholesterol with no change in phospholipid content was observed in erythrocyte membranes, the phospholipid content increased with no change in cholesterol in plasma. CONCLUSIONS: An increase in microviscosity and a consequent decrease in membrane fluidity were evident from the studies of fluorescent hydrocarbon pyrene mobility in the bilayer of erythrocytes in chronic alcoholics. Also, an enhancement in the lipid peroxidation of erythrocytes from alcoholics is indicative of structural damage of membrane resulting from oxidative stress.
AIMS AND METHODS: Alterations in cholesterol and phospholipid contents as well as fluidity and lipid peroxidation in erythrocyte membranes from chronic alcoholic humans were investigated. RESULTS: While an increase in cholesterol with no change in phospholipid content was observed in erythrocyte membranes, the phospholipid content increased with no change in cholesterol in plasma. CONCLUSIONS: An increase in microviscosity and a consequent decrease in membrane fluidity were evident from the studies of fluorescent hydrocarbon pyrene mobility in the bilayer of erythrocytes in chronic alcoholics. Also, an enhancement in the lipid peroxidation of erythrocytes from alcoholics is indicative of structural damage of membrane resulting from oxidative stress.
Authors: Brian M Stott; Mai P Vu; Chisako O McLemore; M Shaun Lund; Elizabeth Gibbons; Taylor J Brueseke; Heather A Wilson-Ashworth; John D Bell Journal: J Lipid Res Date: 2008-02-25 Impact factor: 5.922
Authors: Heather A Wilson-Ashworth; Quinn Bahm; Joshua Erickson; Aaron Shinkle; Mai P Vu; Dixon Woodbury; John D Bell Journal: Biophys J Date: 2006-09-15 Impact factor: 4.033
Authors: Joy G Mohanty; Hem D Shukla; Jefferey D Williamson; Lenore J Launer; Satya Saxena; Joseph M Rifkind Journal: Proteome Sci Date: 2010-03-03 Impact factor: 2.480
Authors: Anne L Heiner; Elizabeth Gibbons; Jeremy L Fairbourn; Laurie J Gonzalez; Chisako O McLemore; Taylor J Brueseke; Allan M Judd; John D Bell Journal: Biophys J Date: 2008-01-11 Impact factor: 4.033