| Literature DB >> 14998527 |
Arnab Pain1, John Woodward, Michael A Quail, Michael J Anderson, Richard Clark, Matthew Collins, Nigel Fosker, Audrey Fraser, David Harris, Natasha Larke, Lee Murphy, Sean Humphray, Susan O'Neil, Mihaela Pertea, Claire Price, Ester Rabbinowitsch, Marie-Adele Rajandream, Steven Salzberg, David Saunders, Kathy Seeger, Sarah Sharp, Tim Warren, David W Denning, Bart Barrell, Neil Hall.
Abstract
Aspergillus fumigatus is the most ubiquitous opportunistic filamentous fungal pathogen of human. As an initial step toward sequencing the entire genome of A. fumigatus, which is estimated to be approximately 30 Mb in size, we have sequenced a 922 kb region, contained within 16 overlapping bacterial artificial chromosome (BAC) clones. Fifty-four percent of the DNA is predicted to be coding with 341 putative protein coding genes. Functional classification of the proteins showed the presence of a higher proportion of enzymes and membrane transporters when compared to those of Saccharomyces cerevisiae. In addition to the nitrate assimilation gene cluster, the quinate utilisation gene cluster is also present on this 922 kb genomic sequence. We observed large scale synteny between A. fumigatus and Aspergillus nidulans by comparing this sequence to the A. nidulans genetic map of linkage group VIII.Entities:
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Year: 2004 PMID： 14998527 DOI： 10.1016/j.fgb.2003.12.003
Source DB: PubMed Journal: Fungal Genet Biol ISSN： 1087-1845 Impact factor: 3.495