| Literature DB >> 14998512 |
Akira Sakurai1, Jiro Yasuda, Hiroko Takano, Yuetsu Tanaka, Masanori Hatakeyama, Hisatoshi Shida.
Abstract
The Gag protein of human T-cell leukemia virus type 1 (HTLV-1) contains the conserved sequences PPxY and PTAP, which are putative viral motifs required for budding (L-domain motifs). We show here that the PPxY motif, but not the PTAP motif, is essential for HTLV-1 virion budding from the plasma membrane. In addition, we show that overexpression of Nedd4 enhances HTLV-1 budding and that Nedd4 interacts with Gag via its WW domain. The HECT domain of Nedd4 is also required for budding. These results indicate that Nedd4 or a Nedd4-related ubiquitin ligase plays a critical role in HTLV-1 budding.Entities:
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Year: 2004 PMID： 14998512 DOI： 10.1016/j.micinf.2003.10.011
Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700