| Literature DB >> 14998344 |
Deepak B Salunke1, Braja G Hazra, Vandana S Pore, Manoj Kumar Bhat, Pallavi B Nahar, Mukund V Deshpande.
Abstract
Bile acid-derived novel amphiphilic topology was designed and synthesized in the form of steroidal dimers. These dimers were tested for antifungal and antiproliferative activity in vitro. N(1),N(3)-Diethylenetriaminebis[cholic acid amide] was found to be active against C. albicans, Y. lipolytica, and B. poitrassi at nanomolar concentration and did not show any effect on cell proliferation. N(1),N(2)-Ethylenediaminebis[deoxycholic acid amide] totally inhibited the growth of human oral cancer (HEp-2) and human breast cancer (MCF-7) cells.Entities:
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Year: 2004 PMID： 14998344 DOI： 10.1021/jm030376y
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446