| Literature DB >> 14998339 |
Yiqian Wan1, Charlotta Wallinder, Berndt Johansson, Mathias Holm, A K Mahalingam, Xiongyu Wu, Milad Botros, Anders Karlén, Anders Pettersson, Fred Nyberg, Lars Fändriks, Anders Hallberg, Mathias Alterman.
Abstract
In this investigation, it is demonstrated that the first nonpeptide AT(1) receptor agonist L-162,313 (1), disclosed in 1994, also acts as an agonist at the AT(2) receptor. In anesthetized rats, administration of compound 1 intravenously or locally in the duodenum increased duodenal mucosal alkaline secretion, effects that were sensitive to the selective AT(2) receptor antagonist PD-123,319. The data strongly suggest that 1 is an AT(2) receptor agonist in vivo. To the best of our knowledge, this substance is the first nonpeptidic low-molecular weight compound with an agonistic effect mediated through the AT(2) receptor.Entities:
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Year: 2004 PMID： 14998339 DOI： 10.1021/jm031031i
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446