STUDY OBJECTIVES: To explore newly-identified respiratory cycle-related electroencephalographic changes (RCREC), which may represent microarousals, as correlates of neurobehavioral outcomes in children with sleep-disordered breathing (SDB). DESIGN: Retrospective. SETTING: University sleep laboratory. PARTICIPANTS: Ten research subjects, aged 6 to 10 years, with and without SDB. INTERVENTION: Polysomnography, Multiple Sleep Latency Tests, and tests of auditory attention before and after clinically-indicated tonsillectomy (n = 9) or hernia repair (n = 1, control). MEASUREMENTS: For the first 3 hours of nocturnal sleep, a computer algorithm quantified the degree to which delta, theta, and alpha electroencephalographic power varied within non-apneic respiratory cycles. Correlations between the RCREC and standard objective measures of SDB, sleepiness, and attention were explored. RESULTS: Five children had SDB (> 1 obstructive apnea per hour of sleep). Preoperative delta, theta, or alpha RCREC were statistically significant (P < .01) in all subjects except 1 without SDB and the 1 control. Theta RCREC correlated with rates of apneas and hypopneas (P = .01) and decreased after the apnea was treated. Postoperative changes in delta and theta RCREC predicted changes in Multiple Sleep Latency Test scores (rho = -0.84, P = .002; rho = -0.64, P = .05), whereas changes in rates of apneas and hypopneas did not (rho = -0.24, P = .50). Postoperative changes in attention tended to correlate with changes in delta RCREC (rho = -0.54, P = .11) more strongly than with changes in rates of apneic events (rho = -0.07, P = .84). CONCLUSIONS: The RCREC may reflect brief but numerous microarousals that could help to explain neurobehavioral consequences of SDB.
STUDY OBJECTIVES: To explore newly-identified respiratory cycle-related electroencephalographic changes (RCREC), which may represent microarousals, as correlates of neurobehavioral outcomes in children with sleep-disordered breathing (SDB). DESIGN: Retrospective. SETTING: University sleep laboratory. PARTICIPANTS: Ten research subjects, aged 6 to 10 years, with and without SDB. INTERVENTION: Polysomnography, Multiple Sleep Latency Tests, and tests of auditory attention before and after clinically-indicated tonsillectomy (n = 9) or hernia repair (n = 1, control). MEASUREMENTS: For the first 3 hours of nocturnal sleep, a computer algorithm quantified the degree to which delta, theta, and alpha electroencephalographic power varied within non-apneic respiratory cycles. Correlations between the RCREC and standard objective measures of SDB, sleepiness, and attention were explored. RESULTS: Five children had SDB (> 1 obstructive apnea per hour of sleep). Preoperative delta, theta, or alpha RCREC were statistically significant (P < .01) in all subjects except 1 without SDB and the 1 control. Theta RCREC correlated with rates of apneas and hypopneas (P = .01) and decreased after the apnea was treated. Postoperative changes in delta and theta RCREC predicted changes in Multiple Sleep Latency Test scores (rho = -0.84, P = .002; rho = -0.64, P = .05), whereas changes in rates of apneas and hypopneas did not (rho = -0.24, P = .50). Postoperative changes in attention tended to correlate with changes in delta RCREC (rho = -0.54, P = .11) more strongly than with changes in rates of apneic events (rho = -0.07, P = .84). CONCLUSIONS: The RCREC may reflect brief but numerous microarousals that could help to explain neurobehavioral consequences of SDB.
Authors: Patrick J Strollo; M Safwan Badr; Michael P Coppola; Samuel A Fleishman; Ofer Jacobowitz; Clete A Kushida Journal: Sleep Date: 2011-12-01 Impact factor: 5.849
Authors: Joel S C Yang; Christian L Nicholas; Gillian M Nixon; Margot J Davey; Vicki Anderson; Adrian M Walker; John A Trinder; Rosemary S C Horne Journal: Sleep Date: 2010-09 Impact factor: 5.849
Authors: Ronald D Chervin; Deborah L Ruzicka; Timothy F Hoban; Judith L Fetterolf; Susan L Garetz; Kenneth E Guire; James E Dillon; Barbara T Felt; Elise K Hodges; Bruno J Giordani Journal: Chest Date: 2012-07 Impact factor: 9.410
Authors: Joel S C Yang; Christian L Nicholas; Gillian M Nixon; Margot J Davey; Vicki Anderson; Adrian M Walker; John Trinder; Rosemary S C Horne Journal: Sleep Breath Date: 2011-05-13 Impact factor: 2.816
Authors: Ronald D Chervin; Susan L Garetz; Deborah L Ruzicka; Elise K Hodges; Bruno J Giordani; James E Dillon; Barbara T Felt; Timothy F Hoban; Kenneth E Guire; Louise M O'Brien; Joseph W Burns Journal: J Clin Sleep Med Date: 2014-08-15 Impact factor: 4.062
Authors: Ronald D Chervin; Deborah L Ruzicka; Bruno J Giordani; Robert A Weatherly; James E Dillon; Elise K Hodges; Carole L Marcus; Kenneth E Guire Journal: Pediatrics Date: 2006-04 Impact factor: 7.124