Literature DB >> 14996709

Biomarkers of esophageal adenocarcinoma and Barrett's esophagus.

Damian T McManus1, Andreea Olaru, Stephen J Meltzer.   

Abstract

The rising incidence and poor prognosis of esophageal adenocarcinoma in the Western world have intensified research efforts into earlier methods of detection of this disease and its relationship to Barrett's esophagus. The progression of Barrett's esophagus to adenocarcinoma has been the focus of particular scrutiny, and a number of potential tissue and serum-based disease biomarkers have emerged. The epidemiology and pathogenesis of esophageal adenocarcinoma are outlined. Tissue biomarkers allowing risk stratification of Barrett's are reviewed as well as strategies currently being used to discover novel biomarkers that will facilitate the early detection of esophageal adenocarcinoma. Finally, the uses of biomarkers as predictive tests for targeted treatments and as surrogate endpoints in chemoprevention trials are considered.

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Year:  2004        PMID： 14996709     DOI： 10.1158/0008-5472.can-03-2438

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  29 in total

1.  Hedgehog signaling activation in the development of squamous cell carcinoma and adenocarcinoma of esophagus.

Authors:  Ling Yang; Li-Shu Wang; Xiaoxin Luke Chen; Zoran Gatalica; Suimin Qiu; Zhihua Liu; Gary Stoner; Hongwei Zhang; Heidi Weiss; Jingwu Xie
Journal:  Int J Biochem Mol Biol       Date:  2012-02-10

2.  TP53 and progression from Barrett's metaplasia to oesophageal adenocarcinoma in a UK population cohort.

Authors:  L Murray; A Sedo; M Scott; D McManus; J M Sloan; L J Hardie; D Forman; C P Wild
Journal:  Gut       Date:  2006-05-08       Impact factor: 23.059

3.  Large intra- and inter-individual variability of genes expression levels limits potential predictive value of molecular diagnosis of dysplasia in Barrett's esophagus.

Authors:  Ewa E Hennig; Michal Mikula; Janina Orlowska; Dorota Jarosz; Andrzej Bielasik; Jaroslaw Regula; Jerzy Ostrowski
Journal:  J Mol Med (Berl)       Date:  2007-10-19       Impact factor: 4.599

4.  Dietary supplement use and risk of neoplastic progression in esophageal adenocarcinoma: a prospective study.

Authors:  Linda M Dong; Alan R Kristal; Ulrike Peters; Jeannette M Schenk; Carissa A Sanchez; Peter S Rabinovitch; Patricia L Blount; Robert D Odze; Kamran Ayub; Brian J Reid; Thomas L Vaughan
Journal:  Nutr Cancer       Date:  2008       Impact factor: 2.900

Review 5.  Role of epigenetic alterations in the pathogenesis of Barrett's esophagus and esophageal adenocarcinoma.

Authors:  Archana Agarwal; Rahul Polineni; Zulfiqar Hussein; Ivette Vigoda; Tushar D Bhagat; Sanchari Bhattacharyya; Anirban Maitra; Amit Verma
Journal:  Int J Clin Exp Pathol       Date:  2012-05-23

6.  Cigarette smoking, body mass index, gastro-esophageal reflux disease, and non-steroidal anti-inflammatory drug use and risk of subtypes of esophageal and gastric cancers by P53 overexpression.

Authors:  Jonine D Figueroa; Mary Beth Terry; Marilie D Gammon; Thomas L Vaughan; Harvey A Risch; Fang-Fang Zhang; David E Kleiner; William P Bennett; Christine L Howe; Robert Dubrow; Susan T Mayne; Joseph F Fraumeni; Wong-Ho Chow
Journal:  Cancer Causes Control       Date:  2008-11-07       Impact factor: 2.506

7.  MicroRNA expression signatures in Barrett's esophagus and esophageal adenocarcinoma.

Authors:  Hushan Yang; Jian Gu; Kenneth K Wang; Wei Zhang; Jinliang Xing; Zhinan Chen; Jaffer A Ajani; Xifeng Wu
Journal:  Clin Cancer Res       Date:  2009-09-08       Impact factor: 12.531

8.  Three-gene immunohistochemical panel adds to clinical staging algorithms to predict prognosis for patients with esophageal adenocarcinoma.

Authors:  Chin-Ann J Ong; Joel Shapiro; Katie S Nason; Jon M Davison; Xinxue Liu; Caryn Ross-Innes; Maria O'Donovan; Winand N M Dinjens; Katharina Biermann; Nicholas Shannon; Susannah Worster; Laura K E Schulz; James D Luketich; Bas P L Wijnhoven; Richard H Hardwick; Rebecca C Fitzgerald
Journal:  J Clin Oncol       Date:  2013-03-18       Impact factor: 44.544

9.  Gastroesophageal reflux leads to esophageal cancer in a surgical model with mice.

Authors:  Jing Hao; Ba Liu; Chung S Yang; Xiaoxin Chen
Journal:  BMC Gastroenterol       Date:  2009-07-23       Impact factor: 3.067

10.  Silencing of tumor necrosis factor receptor 1 by siRNA in EC109 cells affects cell proliferation and apoptosis.

Authors:  Ma Changhui; Ma Tianzhong; Su Zhongjing; Chen Ling; Wang Ning; Zhu Ningxia; Chen Xiancai; Chen Haibin
Journal:  J Biomed Biotechnol       Date:  2009-10-08
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