| Literature DB >> 14996497 |
Martin R Sprick1, Henning Walczak.
Abstract
Two principal pathways for apoptosis initiation exist. One pathway, which is also termed the 'extrinsic' pathway, is mediated by death receptors, a subgroup of the TNF receptor superfamily. The second pathway, which is also referred to as the 'intrinsic' pathway is controlled by members of the Bcl-2 family. A long standing discussion revolves around the question of how these two pathways influence each other in regulating the decision about life or death of a cell. Here, we review our current knowledge about the interactions between these two pathways and discuss current models which could help to resolve previous apparently contradictory results.Entities:
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Year: 2004 PMID： 14996497 DOI： 10.1016/j.bbamcr.2003.11.002
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002