Literature DB >> 14996496

There is more to life and death than mitochondria: Bcl-2 proteins at the endoplasmic reticulum.

Matthew G Annis1, Jeremy A Yethon, Brian Leber, David W Andrews.   

Abstract

Proteins of the Bcl-2 family are important regulators of cell fate. The role of these proteins in controlling mitochondrial apoptotic processes has been extensively investigated, although exact molecular mechanisms are incompletely understood. However, mounting evidence indicates that these proteins also function at the endoplasmic reticulum and other locations within the cell. Both pro- and anti-apoptotic Bcl-2 family members can regulate endoplasmic reticulum calcium, cellular pH and endoplasmic reticulum resident proteins. In this review, we discuss the activities and potential targets of Bcl-2 family members at the endoplasmic reticulum and other cellular locations.

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Year:  2004        PMID： 14996496     DOI： 10.1016/j.bbamcr.2003.07.001

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  19 in total

1.  Deletion of the pro-apoptotic endoplasmic reticulum stress response effector CHOP does not result in improved locomotor function after severe contusive spinal cord injury.

Authors:  Sujata Saraswat Ohri; Melissa A Maddie; Yiping Zhang; Christopher B Shields; Michal Hetman; Scott R Whittemore
Journal:  J Neurotrauma       Date:  2011-11-21       Impact factor: 5.269

2.  Bcl-2 homodimerization involves two distinct binding surfaces, a topographic arrangement that provides an effective mechanism for Bcl-2 to capture activated Bax.

Authors:  Zhi Zhang; Suzanne M Lapolla; Matthew G Annis; Mary Truscott; G Jane Roberts; Yiwei Miao; Yuanlong Shao; Chibing Tan; Jun Peng; Arthur E Johnson; Xuejun C Zhang; David W Andrews; Jialing Lin
Journal:  J Biol Chem       Date:  2004-08-09       Impact factor: 5.157

Review 3.  Mitochondria and endoplasmic reticulum: the lethal interorganelle cross-talk.

Authors:  Ludivine Walter; György Hajnóczky
Journal:  J Bioenerg Biomembr       Date:  2005-06       Impact factor: 2.945

4.  Mutually exclusive subsets of BH3-only proteins are activated by the p53 and c-Jun N-terminal kinase/c-Jun signaling pathways during cortical neuron apoptosis induced by arsenite.

Authors:  Hon Kit Wong; Michael Fricker; Andreas Wyttenbach; Andreas Villunger; Ewa M Michalak; Andreas Strasser; Aviva M Tolkovsky
Journal:  Mol Cell Biol       Date:  2005-10       Impact factor: 4.272

5.  Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes.

Authors:  Ildikò Szabó; Jürgen Bock; Heike Grassmé; Matthias Soddemann; Barbara Wilker; Florian Lang; Mario Zoratti; Erich Gulbins
Journal:  Proc Natl Acad Sci U S A       Date:  2008-09-25       Impact factor: 11.205

6.  Suppression of IP3-mediated calcium release and apoptosis by Bcl-2 involves the participation of protein phosphatase 1.

Authors:  Liping Xu; Dejuan Kong; Liping Zhu; Weijia Zhu; David W Andrews; Tuan H Kuo
Journal:  Mol Cell Biochem       Date:  2006-07-28       Impact factor: 3.396

7.  The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor.

Authors:  Yi-Ping Rong; Geert Bultynck; Ademuyiwa S Aromolaran; Fei Zhong; Jan B Parys; Humbert De Smedt; Gregory A Mignery; H Llewelyn Roderick; Martin D Bootman; Clark W Distelhorst
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-17       Impact factor: 11.205

8.  Distinct targeting pathways for the membrane insertion of tail-anchored (TA) proteins.

Authors:  Vincenzo Favaloro; Milan Spasic; Blanche Schwappach; Bernhard Dobberstein
Journal:  J Cell Sci       Date:  2008-05-13       Impact factor: 5.285

Review 9.  The role of SERCA2a/PLN complex, Ca(2+) homeostasis, and anti-apoptotic proteins in determining cell fate.

Authors:  Elizabeth Vafiadaki; Vasiliki Papalouka; Demetrios A Arvanitis; Evangelia G Kranias; Despina Sanoudou
Journal:  Pflugers Arch       Date:  2008-04-16       Impact factor: 3.657

10.  Differential protection by wildtype vs. organelle-specific Bcl-2 suggests a combined requirement of both the ER and mitochondria in ceramide-mediated caspase-independent programmed cell death.

Authors:  Andrea Deerberg; Justyna Sosna; Lutz Thon; Claus Belka; Dieter Adam
Journal:  Radiat Oncol       Date:  2009-10-09       Impact factor: 3.481
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