Benjamin J D H Chun1, David L Dunner. 1. Department of Psychiatry and Behavioral Science, Center for Anxiety and Depression, University of Washington, Seattle, WA 98105, USA.
Abstract
OBJECTIVES: To determine if the classification of 'antidepressant-induced hypomania' in DSM-IV is supported by available data. METHODS: We reviewed the available scientific literature to examine the incidence of mania and hypomania in non-bipolar patients who were treated with antidepressants. RESULTS: Eighty-nine per cent of studies of antidepressants in major depressive disorder patients reported no cases of treatment-induced hypomania. No instances of treatment-induced hypomania were reported in three large studies of patients with chronic forms of depression. CONCLUSIONS: The rate of antidepressant-induced hypomania in major depressive disorder is within the rate of misdiagnosis of bipolar depression as unipolar. Depressed patients who experience antidepressant-associated hypomania are truly bipolar.
OBJECTIVES: To determine if the classification of 'antidepressant-induced hypomania' in DSM-IV is supported by available data. METHODS: We reviewed the available scientific literature to examine the incidence of mania and hypomania in non-bipolarpatients who were treated with antidepressants. RESULTS: Eighty-nine per cent of studies of antidepressants in major depressive disorderpatients reported no cases of treatment-induced hypomania. No instances of treatment-induced hypomania were reported in three large studies of patients with chronic forms of depression. CONCLUSIONS: The rate of antidepressant-induced hypomania in major depressive disorder is within the rate of misdiagnosis of bipolar depression as unipolar. Depressedpatients who experience antidepressant-associated hypomania are truly bipolar.
Authors: Jess G Fiedorowicz; Jean Endicott; Andrew C Leon; David A Solomon; Martin B Keller; William H Coryell Journal: Am J Psychiatry Date: 2010-11-15 Impact factor: 18.112
Authors: Rashmi Patel; Peter Reiss; Hitesh Shetty; Matthew Broadbent; Robert Stewart; Philip McGuire; Matthew Taylor Journal: BMJ Open Date: 2015-12-14 Impact factor: 2.692