Literature DB >> 14995183

Biomimetic studies on anti-thyroid drugs and thyroid hormone synthesis.

Gouriprasanna Roy1, Munirathinam Nethaji, G Mugesh.   

Abstract

The selenium analogues of anti-thyroid drugs exhibit their anti-thyroid action by a mechanism different from that of MMI. The selenium analogue of MMI and related selenium compounds exhibit high GPx activity, providing a novel method for the reversible inhibition of thyroid hormone biosynthesis.

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Year:  2004        PMID: 14995183     DOI: 10.1021/ja039860g

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN: 0002-7863            Impact factor:   15.419


  2 in total

1.  Se- and s-based thiouracil and methimazole analogues exert different inhibitory mechanisms on type 1 and type 2 deiodinases.

Authors:  Eddy Rijntjes; Philip Moritz Scholz; Govindasamy Mugesh; Josef Köhrle
Journal:  Eur Thyroid J       Date:  2013-11-27

2.  Bioinorganic chemistry in thyroid gland: effect of antithyroid drugs on peroxidase-catalyzed oxidation and iodination reactions.

Authors:  Gouriprasanna Roy; G Mugesh
Journal:  Bioinorg Chem Appl       Date:  2006-11-12       Impact factor: 7.778

  2 in total

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