PURPOSE: To quantify the minimum magnetic resonance imaging (MRI) spatial resolution of the visible deoxygenated microscopic vessels of the human brain at 8 T. MATERIALS AND METHODS: This study compared 8-T gradient echo (GE) images of a human cadaver brain having an in-plane resolution of 195 x 195 microm to corresponding digital photographs of 205 cryomicrotome sections of the same cadaver brain, along with summed images of 25 contiguous cryomicrotome sections. One-millimeter-thick GE images of a 1-cm-thick unfixed whole coronal brain section were acquired using techniques similar to those commonly utilized for 8-T human imaging in vivo. RESULTS: There was excellent MR visualization of the deoxygenated microscopic vessels within the brain down to a resolution of approximately 100 microm. CONCLUSION: By taking advantage of magnetic susceptibility-based blood oxygenation level-dependent (BOLD) contrast, deoxygenated microscopic blood vessels smaller than the pixel dimensions used for imaging can be visualized using a whole-body 8-T MRI system. Copyright 2004 Wiley-Liss, Inc.
PURPOSE: To quantify the minimum magnetic resonance imaging (MRI) spatial resolution of the visible deoxygenated microscopic vessels of the human brain at 8 T. MATERIALS AND METHODS: This study compared 8-T gradient echo (GE) images of a human cadaver brain having an in-plane resolution of 195 x 195 microm to corresponding digital photographs of 205 cryomicrotome sections of the same cadaver brain, along with summed images of 25 contiguous cryomicrotome sections. One-millimeter-thick GE images of a 1-cm-thick unfixed whole coronal brain section were acquired using techniques similar to those commonly utilized for 8-T human imaging in vivo. RESULTS: There was excellent MR visualization of the deoxygenated microscopic vessels within the brain down to a resolution of approximately 100 microm. CONCLUSION: By taking advantage of magnetic susceptibility-based blood oxygenation level-dependent (BOLD) contrast, deoxygenated microscopic blood vessels smaller than the pixel dimensions used for imaging can be visualized using a whole-body 8-T MRI system. Copyright 2004 Wiley-Liss, Inc.
Authors: Ming Yang; Gregory A Christoforidis; Tatiana Figueredo; Johannes T Heverhagen; Amir Abduljalil; Michael V Knopp Journal: Invest Radiol Date: 2005-10 Impact factor: 6.016
Authors: William T C Yuh; Greg A Christoforidis; Regina Maria Koch; Steffen Sammet; Petra Schmalbrock; Ming Yang; Michael V Knopp Journal: Top Magn Reson Imaging Date: 2006-04
Authors: Gregory A Christoforidis; Ming Yang; Marinos S Kontzialis; Douglas G Larson; Amir Abduljalil; Michelle Basso; Weilian Yang; Abhik Ray-Chaudhury; Johannes Heverhagen; Michael V Knopp; Rolf F Barth Journal: Invest Radiol Date: 2009-07 Impact factor: 6.016
Authors: Christoph Moenninghoff; Stefan Maderwald; Jens M Theysohn; Oliver Kraff; Mark E Ladd; Nicolai El Hindy; Johannes van de Nes; Michael Forsting; Isabel Wanke Journal: Eur Radiol Date: 2009-09-18 Impact factor: 5.315
Authors: Bradley P Thomas; E Brian Welch; Blake D Niederhauser; William O Whetsell; Adam W Anderson; John C Gore; Malcolm J Avison; Jeffrey L Creasy Journal: J Magn Reson Imaging Date: 2008-11 Impact factor: 4.813
Authors: Seung Leal Paek; Young Seob Chung; Sun Ha Paek; Jae Ha Hwang; Chul-Ho Sohn; Seung Hong Choi; Young Don Son; Young Bo Kim; Dong Gyu Kim; Kendall H Lee; Zang-Hee Cho Journal: J Korean Med Sci Date: 2013-08-28 Impact factor: 2.153