The MPN mag: introducing a critical area mediating pheromonal and hormonal regulation of male sexual behavior.

Mating behavior in male hamsters is regulated by a chemosensory pathway that converges on the bed nucleus of the stria terminalis (BST) and the medial nucleus of the amygdala (Me). Both the BST and the Me project to the lateral part of the medial preoptic area. Lesion studies have identified a small group of large cells referred to as the magnocellular medial preoptic nucleus (MPN mag) whose integrity is required for normal mating behavior. Our data, summarized within, indicate that the MPN mag is a sexually differentiated nucleus in a large steroid-responsive network that relays pheromonal signals from the sensory systems to the motor areas to affect behavior.