Literature DB >> 14992691

Solution conformation of alpha-conotoxin GIC, a novel potent antagonist of alpha3beta2 nicotinic acetylcholine receptors.

Seung-Wook Chi1, Do-Hyoung Kim, Baldomero M Olivera, J Michael McIntosh, Kyou-Hoon Han.   

Abstract

Alpha-conotoxin GIC is a 16-residue peptide isolated from the venom of the cone snail Conus geographus. Alpha-conotoxin GIC potently blocks the alpha3beta2 subtype of human nicotinic acetylcholine receptor, showing a high selectivity for neuronal versus muscle subtype [McIntosh, Dowell, Watkins, Garrett, Yoshikami, and Olivera (2002) J. Biol. Chem. 277, 33610-33615]. We have now determined the three-dimensional solution structure of alpha-conotoxin GIC by NMR spectroscopy. The structure of alpha-conotoxin GIC is well defined with backbone and heavy atom root mean square deviations (residues 2-16) of 0.53 A and 0.96 A respectively. Structure and surface comparison of alpha-conotoxin GIC with the other alpha4/7 subfamily conotoxins reveals unique structural aspects of alpha-conotoxin GIC. In particular, the structural comparison between alpha-conotoxins GIC and MII indicates molecular features that may confer their similar receptor specificity profile, as well as those that provide the unique binding characteristics of alpha-conotoxin GIC.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 14992691      PMCID： PMC1224189          DOI： 10.1042/BJ20031792

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  44 in total

1.  Pairwise interactions between neuronal alpha7 acetylcholine receptors and alpha-conotoxin ImI.

Authors:  P A Quiram; J J Jones; S M Sine
Journal:  J Biol Chem       Date:  1999-07-09       Impact factor: 5.157

2.  Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein.

Authors:  J L Sussman; M Harel; F Frolow; C Oefner; A Goldman; L Toker; I Silman
Journal:  Science       Date:  1991-08-23       Impact factor: 47.728

Review 3.  The diversity of neuronal nicotinic acetylcholine receptors.

Authors:  P B Sargent
Journal:  Annu Rev Neurosci       Date:  1993       Impact factor: 12.449

4.  The crystal structure of alpha-bungarotoxin at 2.5 A resolution: relation to solution structure and binding to acetylcholine receptor.

Authors:  R A Love; R M Stroud
Journal:  Protein Eng       Date:  1986 Oct-Nov

Review 5.  Physiological diversity of nicotinic acetylcholine receptors expressed by vertebrate neurons.

Authors:  D S McGehee; L W Role
Journal:  Annu Rev Physiol       Date:  1995       Impact factor: 19.318

Review 6.  Chemical shifts as a tool for structure determination.

Authors:  D S Wishart; B D Sykes
Journal:  Methods Enzymol       Date:  1994       Impact factor: 1.600

7.  Improved spectral resolution in cosy 1H NMR spectra of proteins via double quantum filtering.

Authors:  M Rance; O W Sørensen; G Bodenhausen; G Wagner; R R Ernst; K Wüthrich
Journal:  Biochem Biophys Res Commun       Date:  1983-12-16       Impact factor: 3.575

8.  NMR analysis reveals a positively charged hydrophobic domain as a common motif to bound acetylcholine and d-tubocurarine.

Authors:  Y Fraenkel; J M Gershoni; G Navon
Journal:  Biochemistry       Date:  1994-01-25       Impact factor: 3.162

9.  Determining stereo-specific 1H nuclear magnetic resonance assignments from distance geometry calculations.

Authors:  P L Weber; R Morrison; D Hare
Journal:  J Mol Biol       Date:  1988-11-20       Impact factor: 5.469

10.  NMR solution structure of an alpha-bungarotoxin/nicotinic receptor peptide complex.

Authors:  V J Basus; G Song; E Hawrot
Journal:  Biochemistry       Date:  1993-11-23       Impact factor: 3.162
View more
  8 in total

1.  Fast synaptic transmission in the goldfish CNS mediated by multiple nicotinic receptors.

Authors:  Charlotte L Grove; Theresa M Szabo; J Michael McIntosh; Samantha C Do; Robert F Waldeck; Donald S Faber
Journal:  J Physiol       Date:  2010-11-29       Impact factor: 5.182

2.  Characterization of a novel α-conotoxin TxID from Conus textile that potently blocks rat α3β4 nicotinic acetylcholine receptors.

Authors:  Sulan Luo; Dongting Zhangsun; Xiaopeng Zhu; Yong Wu; Yuanyan Hu; Sean Christensen; Peta J Harvey; Muharrem Akcan; David J Craik; J Michael McIntosh
Journal:  J Med Chem       Date:  2013-11-22       Impact factor: 7.446

3.  Structure-function elucidation of a new α-conotoxin, Lo1a, from Conus longurionis.

Authors:  Eline K M Lebbe; Steve Peigneur; Mohitosh Maiti; Prabha Devi; Samuthirapandian Ravichandran; Eveline Lescrinier; Chris Ulens; Etienne Waelkens; Lisette D'Souza; Piet Herdewijn; Jan Tytgat
Journal:  J Biol Chem       Date:  2014-02-24       Impact factor: 5.157

Review 4.  Alpha-conotoxins as pharmacological probes of nicotinic acetylcholine receptors.

Authors:  Layla Azam; J Michael McIntosh
Journal:  Acta Pharmacol Sin       Date:  2009-05-18       Impact factor: 6.150

5.  From crystal structure of α-conotoxin GIC in complex with Ac-AChBP to molecular determinants of its high selectivity for α3β2 nAChR.

Authors:  Bo Lin; Manyu Xu; Xiaopeng Zhu; Yong Wu; Xi Liu; Dongting Zhangsun; Yuanyan Hu; Shi-Hua Xiang; Igor E Kasheverov; Victor I Tsetlin; Xinquan Wang; Sulan Luo
Journal:  Sci Rep       Date:  2016-03-01       Impact factor: 4.379

Review 6.  Residues Responsible for the Selectivity of α-Conotoxins for Ac-AChBP or nAChRs.

Authors:  Bo Lin; Shihua Xiang; Mengsen Li
Journal:  Mar Drugs       Date:  2016-10-11       Impact factor: 5.118

7.  Crystal Structure of the Monomeric Extracellular Domain of α9 Nicotinic Receptor Subunit in Complex With α-Conotoxin RgIA: Molecular Dynamics Insights Into RgIA Binding to α9α10 Nicotinic Receptors.

Authors:  Marios Zouridakis; Athanasios Papakyriakou; Igor A Ivanov; Igor E Kasheverov; Victor Tsetlin; Socrates Tzartos; Petros Giastas
Journal:  Front Pharmacol       Date:  2019-05-01       Impact factor: 5.988

8.  Characterization of an α 4/7-Conotoxin LvIF from Conus lividus That Selectively Blocks α3β2 Nicotinic Acetylcholine Receptor.

Authors:  Man Guo; Jinpeng Yu; Xiaopeng Zhu; Dongting Zhangsun; Sulan Luo
Journal:  Mar Drugs       Date:  2021-07-17       Impact factor: 5.118
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.