Literature DB >> 14991826

A functional polymorphism regulating dopamine beta-hydroxylase influences against Parkinson's disease.

Daniel G Healy1, Patrick M Abou-Sleiman, Tetsutaro Ozawa, Andrew J Lees, Kailash Bhatia, Kourosh R Ahmadi, Ullrich Wullner, Jose Berciano, J Carsten Moller, Christoph Kamm, Katrin Burk, Paolo Barone, Eduardo Tolosa, Niall Quinn, David B Goldstein, Nicholas W Wood, Paolo Barrone.   

Abstract

A functional --1021C --> T polymorphism in the dopamine beta-hydroxylase gene has been demonstrated to regulate plasma DBH activity. We report that individuals with genetically determined low serum DBH activity (genotype T/T) have protection against Parkinson's disease (p = 0.01). In particular, we observed an underrepresentation of the T/T genotype odds ratio = 0.46 (CI = 0.27-0.8). Rather than identifying a haplotype, or a marker in linkage disequilibrium with the risk variant, this to our knowledge is the first report directly linking PD susceptibility with a proven functional variant.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 14991826     DOI： 10.1002/ana.20063

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  16 in total

1.  Interaction between dopamine beta-hydroxylase and interleukin genes increases Alzheimer's disease risk.

Authors:  I Mateo; J Infante; E Rodríguez; J Berciano; O Combarros; J Llorca
Journal:  J Neurol Neurosurg Psychiatry       Date:  2006-02       Impact factor: 10.154

Review 2.  Pharmacogenetic treatments for drug addiction: cocaine, amphetamine and methamphetamine.

Authors:  Colin N Haile; Thomas R Kosten; Therese A Kosten
Journal:  Am J Drug Alcohol Abuse       Date:  2009       Impact factor: 3.829

3.  The catecholamine biosynthetic enzyme dopamine β-hydroxylase (DBH): first genome-wide search positions trait-determining variants acting additively in the proximal promoter.

Authors:  Maja Mustapic; Adam X Maihofer; Manjula Mahata; Yuqing Chen; Dewleen G Baker; Daniel T O'Connor; Caroline M Nievergelt
Journal:  Hum Mol Genet       Date:  2014-06-30       Impact factor: 6.150

Review 4.  The European Multiple System Atrophy-Study Group (EMSA-SG).

Authors:  F Geser; K Seppi; M Stampfer-Kountchev; M Köllensperger; A Diem; J P Ndayisaba; K Ostergaard; E Dupont; A Cardozo; E Tolosa; M Abele; R Dodel; T Klockgether; I Ghorayeb; F Yekhlef; F Tison; C Daniels; F Kopper; G Deuschl; M Coelho; J Ferreira; M M Rosa; C Sampaio; M Bozi; A Schrag; J Hooker; H Kim; T Scaravilli; C J Mathias; C Fowler; N Wood; N Quinn; H Widner; C F Nilsson; O Lindvall; N Schimke; K M Eggert; W Oertel; F del Sorbo; F Carella; A Albanese; M T Pellecchia; P Barone; R Djaldetti; G Meco; C Colosimo; A Gonzalez-Mandly; J Berciano; T Gurevich; N Giladi; M Galitzky; F Ory; O Rascol; C Kamm; K Buerk; S Maass; T Gasser; W Poewe; G K Wenning
Journal:  J Neural Transm (Vienna)       Date:  2005-07-29       Impact factor: 3.575

Review 5.  Past, present and future of human chromaffin cells: role in physiology and therapeutics.

Authors:  Alberto Pérez-Alvarez; Alicia Hernández-Vivanco; Almudena Albillos
Journal:  Cell Mol Neurobiol       Date:  2010-11-24       Impact factor: 5.046

6.  Association between migraine and a functional polymorphism at the dopamine beta-hydroxylase locus.

Authors:  F Fernandez; N Colson; S Quinlan; J MacMillan; R A Lea; L R Griffiths
Journal:  Neurogenetics       Date:  2009-02-14       Impact factor: 2.660

7.  Regulation of rat dopamine beta-hydroxylase gene transcription by early growth response gene 1 (Egr1).

Authors:  Shu-Yuan Cheng; Lidia I Serova; Dina Glazkova; Esther L Sabban
Journal:  Brain Res       Date:  2007-12-05       Impact factor: 3.252

8.  Dopamine beta-hydroxylase -1021C>T association and Parkinson's disease.

Authors:  Owen A Ross; Michael G Heckman; Alexandra I Soto; Nancy N Diehl; Kristoffer Haugarvoll; Carles Vilariño-Güell; Jan O Aasly; Sigrid Sando; J Mark Gibson; Timothy Lynch; Anna Krygowska-Wajs; Grzegorz Opala; Maria Barcikowska; Krzysztof Czyzewski; Ryan J Uitti; Zbigniew K Wszolek; Matthew J Farrer
Journal:  Parkinsonism Relat Disord       Date:  2008-08-22       Impact factor: 4.891

9.  Association of the rs1611115 polymorphism in DBH gene with Parkinson's disease: a meta-analysis.

Authors:  Shan Kang; Mingxia Bi; Xixun Du; Qian Jiao; Hong Jiang
Journal:  Neurol Sci       Date:  2018-09-05       Impact factor: 3.307

10.  DBH -1021C-->T does not modify risk or age at onset in Parkinson's disease.

Authors:  Lani S Chun; Ali Samii; Carolyn M Hutter; Alida Griffith; John W Roberts; Berta C Leis; Anthony D Mosley; P Luke Wander; Karen L Edwards; Haydeh Payami; Cyrus P Zabetian
Journal:  Ann Neurol       Date:  2007-07       Impact factor: 10.422
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.