| Literature DB >> 14991660 |
L Petraccone1, E Erra, A Messere, D Montesarchio, G Piccialli, L De Napoli, G Barone, C Giancola.
Abstract
Targeting double-stranded DNA with homopyrimidine PNAs results in strand displacement complexes PNA/DNA/PNA rather than PNA/DNA/DNA triplex structures. Not much is known about the binding properties of DNA-PNA chimeras. A 16-mer 5'-DNA-3'-p-(N)PNA(C) has been investigated for its ability to hybridize a complementary duplex DNA by DSC, CD, and molecular modeling studies. The obtained results showed the formation of a triplex structure having similar, if not slightly higher, stability compared to the same all-DNA complex. Copyright 2004 Wiley Periodicals, Inc.Entities:
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Year: 2004 PMID： 14991660 DOI： 10.1002/bip.10599
Source DB: PubMed Journal: Biopolymers ISSN： 0006-3525 Impact factor: 2.505