BACKGROUND: Periconceptional folic acid supplementation is suggested to prevent orofacial clefts (OFCs). Other B vitamins however may be beneficial as well. AIM OF THE STUDY: To investigate the maternal periconceptional dietary intake of thiamine, riboflavin, niacin, pyridoxine and cobalamin in association with the occurrence of OFC. METHODS: Two hundred and six mothers of a child with nonsyndromic OFC and 203 control mothers filled out a general questionnaire and a food frequency questionnaire around 14 months postpartum as a proxy for periconceptional intake. After exclusion of known pregnant and lactating mothers, those who reported to have altered their diet compared to the periconceptional period, and mothers with incidental folic acid supplement use periconceptionally, data of 182 OFC mothers and 173 controls were analysed. After logarithmic transformation, geometric means (P5-P95) were calculated and compared between the groups. After subsequent adjustment for energy, quintiles of dietary B vitamin intake were created. RESULTS: The periconceptional intake of thiamine, niacin and pyridoxine was significantly lower in mothers of an OFC child. A trend towards risk reduction for OFC with increasing dietary intake was demonstrated for thiamine (p = 0.04) and pyridoxine (p = 0.03). Risk reductions were only demonstrated in women using folic acid supplements periconceptionally. Supplement users tended to consume a diet richer in B vitamins. CONCLUSIONS: Periconceptional intake of thiamine, niacin and pyridoxine seems to contribute to the prevention of OFC.
BACKGROUND: Periconceptional folic acid supplementation is suggested to prevent orofacial clefts (OFCs). Other B vitamins however may be beneficial as well. AIM OF THE STUDY: To investigate the maternal periconceptional dietary intake of thiamine, riboflavin, niacin, pyridoxine and cobalamin in association with the occurrence of OFC. METHODS: Two hundred and six mothers of a child with nonsyndromic OFC and 203 control mothers filled out a general questionnaire and a food frequency questionnaire around 14 months postpartum as a proxy for periconceptional intake. After exclusion of known pregnant and lactating mothers, those who reported to have altered their diet compared to the periconceptional period, and mothers with incidental folic acid supplement use periconceptionally, data of 182 OFC mothers and 173 controls were analysed. After logarithmic transformation, geometric means (P5-P95) were calculated and compared between the groups. After subsequent adjustment for energy, quintiles of dietary B vitamin intake were created. RESULTS: The periconceptional intake of thiamine, niacin and pyridoxine was significantly lower in mothers of an OFC child. A trend towards risk reduction for OFC with increasing dietary intake was demonstrated for thiamine (p = 0.04) and pyridoxine (p = 0.03). Risk reductions were only demonstrated in women using folic acid supplements periconceptionally. Supplement users tended to consume a diet richer in B vitamins. CONCLUSIONS: Periconceptional intake of thiamine, niacin and pyridoxine seems to contribute to the prevention of OFC.
Authors: Gary M Shaw; Stein Emil Vollset; Suzan L Carmichael; Wei Yang; Richard H Finnell; Henk Blom; Per M Ueland Journal: Pediatr Res Date: 2009-11 Impact factor: 3.756
Authors: Vijaya Kancherla; Paul A Romitti; Lixian Sun; John C Carey; Trudy L Burns; Anna Maria Siega-Riz; Charlotte M Druschel; Angela E Lin; Richard S Olney Journal: Eur J Med Genet Date: 2014-02-24 Impact factor: 2.708
Authors: Abee L Boyles; Allen J Wilcox; Jack A Taylor; Min Shi; Clarice R Weinberg; Klaus Meyer; Ase Fredriksen; Per Magne Ueland; Anne Marte W Johansen; Christian A Drevon; Astanand Jugessur; Truc Nguyen Trung; Håkon K Gjessing; Stein Emil Vollset; Jeffrey C Murray; Kaare Christensen; Rolv T Lie Journal: Genet Epidemiol Date: 2009-04 Impact factor: 2.135