| Literature DB >> 14990315 |
A van Remoortere1, H J Vermeer, A M van Roon, J A Langermans, A W Thomas, R A Wilson, I van die, D H van den Eijnden, K Agoston, J Kérèkgyarto, J F G Vliegenthart, J P Kamerling, G J van dam, C H Hokke, A M Deelder.
Abstract
The development of the humoral anti-glycan immune response of chimpanzees, either or not vaccinated with radiation-attenuated Schistosoma mansoni cercariae, was followed during 1 year after infection with S. mansoni. During the acute phase of infection both the vaccinated and the control chimpanzees produce high levels of immunoglobulin G (IgG) antibodies against carbohydrate structures that are characteristic for schistosomes carrying the Fucalpha1-3GalNAc and Fucalpha1-2Fucalpha1-3GlcNAc motifs, but not to the more widespread occurring structures GalNAcbeta1-4GlcNAc, GalNAcbeta1-4(Fucalpha1-3)GlcNAc, and Galbeta1-4(Fucalpha1-3)GlcNAc (Lewis(x)). In addition, high levels of IgM antibodies were found against the trimeric Lewis(x) epitope. Apparently, the schistosome-characteristic carbohydrate structures are dominant epitopes in the anti-glycan humoral immune response of the chimpanzees. All chimpanzees showed an increase in the level of antibodies against most of the carbohydrate structures tested directly after vaccination, peaking at challenge time and during the acute phase of infection. With the exception of anti-F-LDN antibody responses, the anti-carbohydrate antibody responses upon schistosome infection of the vaccinated animals were muted in comparison to the control animals.Entities:
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Year: 2003 PMID： 14990315 DOI： 10.1016/j.exppara.2003.12.005
Source DB: PubMed Journal: Exp Parasitol ISSN： 0014-4894 Impact factor: 2.011