AIMS: To investigate maternal and neonatal factors in Down syndrome (DS) at birth, the impact of a congenital heart defect (CHD) on these factors and changes over time. METHODS: Medical data of children with DS born in northern Sweden in the periods 1973-1980 (n = 219) and 1995-1998 (n = 88) obtained from the Swedish Medical Birth Register were compared. A comparison with the general population on a group level was also made. RESULTS: The main finding was a reduction in infant mortality in DS, from 14.2% to 2.3% in 1995-1998 (p < 0.001), but this was still significantly higher than in the general population. The rate of Caesarean sections increased over time (from 14.5% to 27.3%, p < 0.05) even after adjustment for increased maternal age. No change over time was detected in the following rates: premature birth (gestational age < or = 36) (25%); asphyxia (5-min Apgar score < or = 6) (8%); low birthweight (< 2500 g) (14%); or small for gestational age (SGA) (14%); all rates were significantly higher than those of the general population. A CHD did not seem to influence the rates of these factors in a logistic regression model. CONCLUSION: Infant mortality decreased substantially over time in the DS group, whereas there was no reduction in the rate of asphyxia, SGA, low birthweight or prematurity. The presence of a CHD did not influence any of the neonatal factors studied.
AIMS: To investigate maternal and neonatal factors in Down syndrome (DS) at birth, the impact of a congenital heart defect (CHD) on these factors and changes over time. METHODS: Medical data of children with DS born in northern Sweden in the periods 1973-1980 (n = 219) and 1995-1998 (n = 88) obtained from the Swedish Medical Birth Register were compared. A comparison with the general population on a group level was also made. RESULTS: The main finding was a reduction in infant mortality in DS, from 14.2% to 2.3% in 1995-1998 (p < 0.001), but this was still significantly higher than in the general population. The rate of Caesarean sections increased over time (from 14.5% to 27.3%, p < 0.05) even after adjustment for increased maternal age. No change over time was detected in the following rates: premature birth (gestational age < or = 36) (25%); asphyxia (5-min Apgar score < or = 6) (8%); low birthweight (< 2500 g) (14%); or small for gestational age (SGA) (14%); all rates were significantly higher than those of the general population. A CHD did not seem to influence the rates of these factors in a logistic regression model. CONCLUSION:Infant mortality decreased substantially over time in the DS group, whereas there was no reduction in the rate of asphyxia, SGA, low birthweight or prematurity. The presence of a CHD did not influence any of the neonatal factors studied.
Authors: D J Wilkinson; J J Fitzsimons; P A Dargaville; N T Campbell; P M Loughnan; P N McDougall; J F Mills Journal: Arch Dis Child Fetal Neonatal Ed Date: 2006-07 Impact factor: 5.747
Authors: Lora J H Bean; Emily G Allen; Stuart W Tinker; Natasha D Hollis; Adam E Locke; Charlotte Druschel; Charlotte A Hobbs; Leslie O'Leary; Paul A Romitti; Marjorie H Royle; Claudine P Torfs; Kenneth J Dooley; Sallie B Freeman; Stephanie L Sherman Journal: Birth Defects Res A Clin Mol Teratol Date: 2011-08-24
Authors: S Trent Rosenbloom; Tracy L McGregor; Qingxia Chen; Angel Qi An; Stephanie Hsu; William D Dupont Journal: AMIA Annu Symp Proc Date: 2010-11-13
Authors: Michel Emile Weijerman; A Marceline van Furth; Maurike D van der Mooren; Miriam M van Weissenbruch; Lukas Rammeloo; Chantal J M Broers; Reinoud J B J Gemke Journal: Eur J Pediatr Date: 2010-04-23 Impact factor: 3.183