Literature DB >> 14988107

TOPALi: software for automatic identification of recombinant sequences within DNA multiple alignments.

Iain Milne1, Frank Wright, Glenn Rowe, David F Marshall, Dirk Husmeier, Gràinne McGuire.   

Abstract

SUMMARY: TOPALi is a new Java graphical analysis application that allows the user to identify recombinant sequences within a DNA multiple alignment (either automatically or via manual investigation). TOPALi allows a choice of three statistical methods to predict the positions of breakpoints due to past recombination. The breakpoint predictions are then used to identify putative recombinant sequences and their relationships to other sequences. In addition to its sophisticated interface, TOPALi can import many sequence formats, estimate and display phylogenetic trees and allow interactive analysis and/or automatic HTML report generation. AVAILABILITY: TOPALi is freely available from http://www.bioss.ac.uk/software.html

Mesh：

Year:  2004        PMID： 14988107     DOI： 10.1093/bioinformatics/bth155

Source DB:  PubMed          Journal:  Bioinformatics        ISSN： 1367-4803            Impact factor:   6.937


  108 in total

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