Literature DB >> 14988008

The effects of clozapine on the GSK-3-mediated signaling pathway.

Ung Gu Kang1, Myoung Suk Seo, Myoung-Sun Roh, Yeni Kim, Se Chang Yoon, Yong Sik Kim.   

Abstract

We investigated the effect of 10 microM clozapine on the activity of glycogen synthase kinase-3beta (GSK-3beta) and its upstream and downstream molecules in SH-SY5Y human neuroblastoma cells. Clozapine activates both Akt- and Dvl-mediated phosphorylation of GSK-3beta through phosphorylation at Ser9, and increased total cellular and intranuclear levels of beta-catenin. Pretreatment with the specific inhibitor of the phosphatidylinositol 3-kinase (PI3K)-Akt pathway, LY294002 (20 microM), prevented the phosphorylation of Akt but did not affect the phosphorylation of GSK-3beta. These results suggest that clozapine regulates the phosphorylation of GSK-3beta through Wnt signal pathways involving Dvl upstream but not through the PI3K-Akt pathway in SH-SY5Y cells.

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Year:  2004        PMID： 14988008     DOI： 10.1016/S0014-5793(04)00082-1

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  36 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  2010-12-27       Impact factor: 11.205

4.  Elevated DISC1 transcript levels in PBMCs during acute psychosis in patients with schizophrenia.

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Review 5.  Antipsychotic drug mechanisms: links between therapeutic effects, metabolic side effects and the insulin signaling pathway.

Authors:  R R Girgis; J A Javitch; J A Lieberman
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6.  Examination of methylphenidate-mediated behavior regulation by glycogen synthase kinase-3 in mice.

Authors:  Marjelo A Mines; Eleonore Beurel; Richard S Jope
Journal:  Eur J Pharmacol       Date:  2012-10-23       Impact factor: 4.432

7.  The activation of the Akt/PKB signalling pathway in the brains of clozapine-exposed rats is linked to hyperinsulinemia and not a direct drug effect.

Authors:  G C Smith; H McEwen; J D Steinberg; P R Shepherd
Journal:  Psychopharmacology (Berl)       Date:  2014-05-07       Impact factor: 4.530

8.  Early effects of mood stabilizers on the Akt/GSK-3beta signaling pathway and on cell survival and proliferation.

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9.  Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice.

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Journal:  PLoS Biol       Date:  2010-06-08       Impact factor: 8.029

10.  Abnormalities in brain structure and behavior in GSK-3alpha mutant mice.

Authors:  Oksana Kaidanovich-Beilin; Tatiana V Lipina; Keizo Takao; Matthijs van Eede; Satoko Hattori; Christine Laliberté; Mustafa Khan; Kenichi Okamoto; John W Chambers; Paul J Fletcher; Katrina MacAulay; Bradley W Doble; Mark Henkelman; Tsuyoshi Miyakawa; John Roder; James R Woodgett
Journal:  Mol Brain       Date:  2009-11-19       Impact factor: 4.041
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