Literature DB >> 14987997

Antiviral activity of caspase inhibitors: effect on picornaviral 2A proteinase.

Luiza Deszcz1, Joachim Seipelt, Elena Vassilieva, Andreas Roetzer, Ernst Kuechler.   

Abstract

Peptide-based fluoromethyl ketones have been considered for many years to be highly specific caspase inhibitors distinctly blocking the progress of apoptosis in a variety of systems. Here we demonstrate that these compounds can significantly reduce rhinovirus multiplication in cell culture. In their methylated forms they block eIF4GI cleavage in vivo and in vitro and inhibit the activity of picornaviral 2A proteinases.

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Year:  2004        PMID： 14987997     DOI： 10.1016/S0014-5793(04)00069-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  19 in total

1.  Ex vivo and in vivo inhibition of human rhinovirus replication by a new pseudosubstrate of viral 2A protease.

Authors:  Nisrine Falah; Sébastien Violot; Didier Décimo; Fatma Berri; Marie-Laure Foucault-Grunenwald; Théophile Ohlmann; Isabelle Schuffenecker; Florence Morfin; Bruno Lina; Béatrice Riteau; Jean-Claude Cortay
Journal:  J Virol       Date:  2011-11-09       Impact factor: 5.103

2.  Two interferon-independent double-stranded RNA-induced host defense strategies suppress the common cold virus at warm temperature.

Authors:  Ellen F Foxman; James A Storer; Kiran Vanaja; Andre Levchenko; Akiko Iwasaki
Journal:  Proc Natl Acad Sci U S A       Date:  2016-07-11       Impact factor: 11.205

3.  Inhibition of polyprotein processing and RNA replication of human rhinovirus by pyrrolidine dithiocarbamate involves metal ions.

Authors:  B M Krenn; B Holzer; E Gaudernak; A Triendl; F J van Kuppeveld; J Seipelt
Journal:  J Virol       Date:  2005-11       Impact factor: 5.103

4.  Nucleocytoplasmic traffic disorder induced by cardioviruses.

Authors:  Peter V Lidsky; Stanleyson Hato; Maryana V Bardina; Alexei G Aminev; Ann C Palmenberg; Eugene V Sheval; Vladimir Y Polyakov; Frank J M van Kuppeveld; Vadim I Agol
Journal:  J Virol       Date:  2006-03       Impact factor: 5.103

5.  Bidirectional increase in permeability of nuclear envelope upon poliovirus infection and accompanying alterations of nuclear pores.

Authors:  George A Belov; Peter V Lidsky; Olga V Mikitas; Denise Egger; Konstantin A Lukyanov; Kurt Bienz; Vadim I Agol
Journal:  J Virol       Date:  2004-09       Impact factor: 5.103

6.  Interactions between viral and prokaryotic pathogens in a mixed infection with cardiovirus and mycoplasma.

Authors:  Peter V Lidsky; Lyudmila I Romanova; Marina S Kolesnikova; Maryana V Bardina; Elena V Khitrina; Stanleyson V Hato; Frank J M van Kuppeveld; Vadim I Agol
Journal:  J Virol       Date:  2009-07-15       Impact factor: 5.103

7.  Theiler's virus-induced intrinsic apoptosis in M1-D macrophages is Bax mediated and restricts virus infectivity: a mechanism for persistence of a cytolytic virus.

Authors:  Kyung-No Son; Robert P Becker; Patricia Kallio; Howard L Lipton
Journal:  J Virol       Date:  2008-02-20       Impact factor: 5.103

8.  Amiloride derivatives inhibit coxsackievirus B3 RNA replication.

Authors:  David N Harrison; Elena V Gazina; Damian F Purcell; David A Anderson; Steven Petrou
Journal:  J Virol       Date:  2007-11-21       Impact factor: 5.103

9.  An antiviral peptide inhibitor that is active against picornavirus 2A proteinases but not cellular caspases.

Authors:  Luiza Deszcz; Regina Cencic; Carla Sousa; Ernst Kuechler; Tim Skern
Journal:  J Virol       Date:  2006-10       Impact factor: 5.103

10.  Suppression of human T cell proliferation by the caspase inhibitors, z-VAD-FMK and z-IETD-FMK is independent of their caspase inhibition properties.

Authors:  C P Lawrence; S C Chow
Journal:  Toxicol Appl Pharmacol       Date:  2012-09-12       Impact factor: 4.219
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