| Literature DB >> 14987820 |
Luisa Savini1, Luisa Chiasserini, Valter Travagli, Cesare Pellerano, Ettore Novellino, Sofia Cosentino, M Barbara Pisano.
Abstract
A series of 3- and 5-methylthiophene-2-carboxaldehyde alpha-(N)-heterocyclichydrazones were synthesized and submitted to an in vitro investigation of their anticancer, anti-HIV and antimicrobial activities. Some of the newly synthesized compounds were found to possess antiproliferative properties, whereas no anti-HIV activity was seen; the most active of the series was the derivative 2i, which exhibited tumour growth inhibition activity against all cell lines displaying GI50 values between 1.63 and 26.5 microM. The title compounds were generally ineffective against Gram-positive and Gram-negative bacteria, while showed a moderate antifungal activity against C. albicans and A. fumigatus.Entities:
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Year: 2004 PMID： 14987820 DOI： 10.1016/j.ejmech.2003.09.012
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514