BACKGROUND: In developed countries, the introduction of highly active antiretroviral therapy (HAART) has greatly improved survival and quality of life in HIV-infected children. Nevertheless, worrisome metabolic and bone alterations are beginning to be observed. OBJECTIVE: To evaluate the prevalence of alterations in bone mineral density and possible associated factors in a cohort of HIV-infected children receiving HAART. PATIENTS AND METHODS: Bone dual energy X-ray absorptiometry (DEXA) was performed in 50 HIV-infected children in a tertiary hospital in Madrid after a median length of HAART of 54 months. Subsequently, the group with bone mineral loss was compared with the group without bone mineral loss. RESULTS: Forty percent of the children studied had decreased bone mineral density, of which 36 % had osteopenia (18/50) and 4 % had osteoporosis (2/50). No statistically significant differences were found between the two groups in any of the factors analyzed. CONCLUSIONS: The prevalence of decreased bone mineral density in our cohort of HIV-infected children receiving HAART is high. The etiology and factors associated with this alteration are still not well known.
BACKGROUND: In developed countries, the introduction of highly active antiretroviral therapy (HAART) has greatly improved survival and quality of life in HIV-infectedchildren. Nevertheless, worrisome metabolic and bone alterations are beginning to be observed. OBJECTIVE: To evaluate the prevalence of alterations in bone mineral density and possible associated factors in a cohort of HIV-infectedchildren receiving HAART. PATIENTS AND METHODS: Bone dual energy X-ray absorptiometry (DEXA) was performed in 50 HIV-infectedchildren in a tertiary hospital in Madrid after a median length of HAART of 54 months. Subsequently, the group with bone mineral loss was compared with the group without bone mineral loss. RESULTS: Forty percent of the children studied had decreased bone mineral density, of which 36 % had osteopenia (18/50) and 4 % had osteoporosis (2/50). No statistically significant differences were found between the two groups in any of the factors analyzed. CONCLUSIONS: The prevalence of decreased bone mineral density in our cohort of HIV-infectedchildren receiving HAART is high. The etiology and factors associated with this alteration are still not well known.
Authors: Stephen M Arpadi; Donald J McMahon; Elaine J Abrams; Mahrukh Bamji; Murli Purswani; Ellen S Engelson; Mary Horlick; Elizabeth Shane Journal: Am J Clin Nutr Date: 2012-01-18 Impact factor: 7.045
Authors: M Isabel Gonzalez-Tome; Jose Tomas Ramos Amador; M Jose Mellado Peña; M Luisa Navarro Gomez; Pablo Rojo Conejo; Pablo Martin Fontelos Journal: BMC Infect Dis Date: 2008-10-22 Impact factor: 3.090