Literature DB >> 14987016

A two-directional synthesis of (+/-)-perhydrohistrionicotoxin.

Robert A Stockman1, Alex Sinclair, Louise G Arini, Peter Szeto, David L Hughes.   

Abstract

An entirely two-directional synthesis of (+/-)-perhydrohistrionicotoxin is presented, utilizing a tandem oxime formation/Michael addition/[3 + 2] cycloaddition as the key step. This approach also constitutes formal syntheses of (+/-)-histrionicotoxin and (+/-)-histrionicotoxin 235A.

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Year:  2004        PMID： 14987016     DOI： 10.1021/jo035639a

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  4 in total

1.  Aza-[3 + 3] Annulations: A New Unified Strategy in Alkaloid Synthesis.

Authors:  Grant S Buchanan; John B Feltenberger; Richard P Hsung
Journal:  Curr Org Synth       Date:  2010-08-01       Impact factor: 1.975

2.  Causation in a cascade: the origins of selectivities in intramolecular nitrone cycloadditions.

Authors:  Elizabeth H Krenske; Sesil Agopcan; Viktorya Aviyente; K N Houk; Brian A Johnson; Andrew B Holmes
Journal:  J Am Chem Soc       Date:  2012-07-12       Impact factor: 15.419

3.  Two-directional synthesis as a tool for diversity-oriented synthesis: Synthesis of alkaloid scaffolds.

Authors:  Kieron M G O'Connell; Monica Díaz-Gavilán; Warren R J D Galloway; David R Spring
Journal:  Beilstein J Org Chem       Date:  2012-06-06       Impact factor: 2.883

4.  E- and Z-, di- and tri-substituted alkenyl nitriles through catalytic cross-metathesis.

Authors:  Yucheng Mu; Thach T Nguyen; Ming Joo Koh; Richard R Schrock; Amir H Hoveyda
Journal:  Nat Chem       Date:  2019-04-01       Impact factor: 24.427
  4 in total

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