Literature DB >> 14986859

Heat shock proteins and aging in Drosophila melanogaster.

Geneviève Morrow1, Robert M Tanguay.   

Abstract

Heat shock proteins (Hsps) are conserved molecular chaperones that are upregulated following exposure to environmental stress and during aging. The mechanisms underlying the aging process are only beginning to be understood. The beneficial effects of Hsps on aging revealed in mild stress and overexpression experiments suggest that these proteins are part of an important cell protection system rather than being unspecific molecular chaperones. Among the Hsps families, small Hsps have the greatest influence on aging and the modulation of their expression during aging in Drosophila suggest that they are involved in pathways of longevity determination.

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Year:  2003        PMID： 14986859     DOI： 10.1016/j.semcdb.2003.09.023

Source DB:  PubMed          Journal:  Semin Cell Dev Biol        ISSN： 1084-9521            Impact factor:   7.727


  18 in total

1.  Stress under the dam: meeting report of the Fourth International Workshop on the Molecular Biology of Stress Responses.

Authors:  R William Currie; Tangchun Wu; Robert M Tanguay
Journal:  Cell Stress Chaperones       Date:  2004       Impact factor: 3.667

2.  Genes that may modulate longevity in C. elegans in both dauer larvae and long-lived daf-2 adults.

Authors:  Peter Ruzanov; Donald L Riddle; Marco A Marra; Sheldon J McKay; Steven M Jones
Journal:  Exp Gerontol       Date:  2007-04-21       Impact factor: 4.032

Review 3.  Cellular stress response pathways and ageing: intricate molecular relationships.

Authors:  Nikos Kourtis; Nektarios Tavernarakis
Journal:  EMBO J       Date:  2011-05-17       Impact factor: 11.598

4.  Differences in the chaperone-like activities of the four main small heat shock proteins of Drosophila melanogaster.

Authors:  Geneviève Morrow; John J Heikkila; Robert M Tanguay
Journal:  Cell Stress Chaperones       Date:  2006       Impact factor: 3.667

5.  A chaperone pathway in protein disaggregation. Hsp26 alters the nature of protein aggregates to facilitate reactivation by Hsp104.

Authors:  Anil G Cashikar; Martin Duennwald; Susan L Lindquist
Journal:  J Biol Chem       Date:  2005-04-20       Impact factor: 5.157

Review 6.  Heat shock proteins and Drosophila aging.

Authors:  John Tower
Journal:  Exp Gerontol       Date:  2010-09-16       Impact factor: 4.032

7.  Tissue-specific targeting of Hsp26 has no effect on heat resistance of neural function in larval Drosophila.

Authors:  Viara Mileva-Seitz; Chengfeng Xiao; Laurent Seroude; R Meldrum Robertson
Journal:  Cell Stress Chaperones       Date:  2008-02-15       Impact factor: 3.667

8.  Effects of small Hsp genes on developmental stability and microenvironmental canalization.

Authors:  Kazuo H Takahashi; Lea Rako; Toshiyuki Takano-Shimizu; Ary A Hoffmann; Siu F Lee
Journal:  BMC Evol Biol       Date:  2010-09-16       Impact factor: 3.260

Review 9.  Hsps and aging.

Authors:  John Tower
Journal:  Trends Endocrinol Metab       Date:  2009-04-24       Impact factor: 12.015

10.  Ayurvedic Amalaki Rasayana promotes improved stress tolerance and thus has anti-aging effects in Drosophila melanogaster.

Authors:  Vibha Dwivedi; Subhash C Lakhotia
Journal:  J Biosci       Date:  2016-12       Impact factor: 1.826
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