Literature DB >> 1498579

Cerebral metabolic dysfunction in AIDS: findings in a sample with and without dementia.

W G van Gorp1, M A Mandelkern, M Gee, C H Hinkin, C E Stern, D K Paz, W Dixon, G Evans, F Flynn, C J Frederick.   

Abstract

Positron-emission tomography was coupled with neurological and neuropsychological evaluation to study regional cerebral activity and neurologic status in two groups. Seventeen patients with full-blown AIDS and 14 seronegative control subjects were studied using [18F]2-fluoro-2-deoxy-D-glucose in a resting state. The AIDS group had relative regional hypermetabolism in the basal ganglia and thalamus; stepwise multiple-regression analyses revealed a significant relationship for the AIDS group between temporal lobe metabolism and severity of dementia on the AIDS Dementia Complex Rating Scale. These results suggest that the basal ganglia, thalamus, and temporal lobes are differentially affected in AIDS.

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Year:  1992        PMID： 1498579     DOI： 10.1176/jnp.4.3.280

Source DB:  PubMed          Journal:  J Neuropsychiatry Clin Neurosci        ISSN： 0895-0172            Impact factor:   2.198


  21 in total

1.  Increased subcortical neural activity among HIV+ individuals during a lexical retrieval task.

Authors:  April D Thames; Philip Sayegh; Kevin Terashima; Jessica M Foley; Andrew Cho; Alyssa Arentoft; Charles H Hinkin; Susan Y Bookheimer
Journal:  Neurobiol Dis       Date:  2015-10-17       Impact factor: 5.996

2.  Increased Cortical Cerebral Blood Flow in Asymptomatic Human Immunodeficiency Virus-Infected Subjects.

Authors:  Souvik Sen; Hongyu An; Prema Menezes; Jonathan Oakes; Joseph Eron; Weili Lin; Kevin Robertson; William Powers
Journal:  J Stroke Cerebrovasc Dis       Date:  2016-05-05       Impact factor: 2.136

Review 3.  Brain PET Imaging: Value for Understanding the Pathophysiology of HIV-associated Neurocognitive Disorder (HAND).

Authors:  Sanhita Sinharay; Dima A Hammoud
Journal:  Curr HIV/AIDS Rep       Date:  2019-02       Impact factor: 5.071

4.  Diffusion tensor imaging of patients with HIV and normal-appearing white matter on MR images of the brain.

Authors:  C G Filippi; A M Ulug; E Ryan; S J Ferrando; W van Gorp
Journal:  AJNR Am J Neuroradiol       Date:  2001-02       Impact factor: 3.825

Review 5.  Role of nuclear medicine in neuroHIV: PET, SPECT, and beyond.

Authors:  Mike Sathekge; Alicia McFarren; Ekaterina Dadachova
Journal:  Nucl Med Commun       Date:  2014-08       Impact factor: 1.690

Review 6.  Dopaminergic impact of cART and anti-depressants on HIV neuropathogenesis in older adults.

Authors:  Stephanie M Matt; Peter J Gaskill
Journal:  Brain Res       Date:  2019-08-21       Impact factor: 3.252

7.  Impact of HIV and a history of marijuana dependence on procedural learning among individuals with a history of substance dependence.

Authors:  Raul Gonzalez; Randi M Schuster; Jasmin Vassileva; Eileen M Martin
Journal:  J Clin Exp Neuropsychol       Date:  2011-06-24       Impact factor: 2.475

Review 8.  Neuropsychiatric manifestations of HIV infection and AIDS.

Authors:  Benoit Dubé; Tami Benton; Dean G Cruess; Dwight L Evans
Journal:  J Psychiatry Neurosci       Date:  2005-07       Impact factor: 6.186

9.  Deficits in complex motor functions, despite no evidence of procedural learning deficits, among HIV+ individuals with history of substance dependence.

Authors:  Raul Gonzalez; Joanna Jacobus; Anup K Amatya; Phillip J Quartana; Jasmin Vassileva; Eileen M Martin
Journal:  Neuropsychology       Date:  2008-11       Impact factor: 3.295

Review 10.  Positron emission tomography in patients suffering from HIV-1 infection.

Authors:  Mike Sathekge; Ingeborg Goethals; Alex Maes; Christophe van de Wiele
Journal:  Eur J Nucl Med Mol Imaging       Date:  2009-04-07       Impact factor: 9.236
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