| Literature DB >> 14984806 |
Tetsuya Tachibana1, Shin Saito, Shozo Tomonaga, Tomo Takagi, Ei-Suke Saito, Tomonori Nakanishi, Tomoyuki Koutoku, Akira Tsukada, Takeshi Ohkubo, Tim Boswell, Mitsuhiro Furuse.
Abstract
Prolactin-releasing peptide (PrRP) is one of the inhibitory factors in feeding regulation of mammals. However, no information is available for avian species. The present study was done to clarify the effect of intracerebroventricular (ICV) injection of PrRP on feeding in chicks. Firstly, we found that ICV injection of PrRP (94-1500 pmol) significantly increased food intake in chicks. The result was completely different from those obtained in mammals. The orexigenic effect of PrRP was significantly weaker than that of neuropeptide Y (NPY), a potent orexigenic peptide, on an equimolar basis. The orexigenic effect of NPY was further enhanced with coinjection of PrRP. These results suggest the existence of a novel orexigenic mechanism in the chick brain, which might differ from NPY-involved feeding regulatory pathway. In addition, ICV injection of PrRP significantly decreased the rectal temperature, but the effect was weaker than that of NPY, suggesting that PrRP may inhibit energy expenditure in chicks. Taken together, we showed here that PrRP may be involved in the regulation of both feeding behavior and energy metabolism in the chick brain.Entities:
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Year: 2004 PMID： 14984806 DOI： 10.1016/j.physbeh.2003.12.005
Source DB: PubMed Journal: Physiol Behav ISSN： 0031-9384