OBJECTIVE: We have tested the relapse-preventive effect of citalopram when compared with placebo in 282 patients with Seasonal Affective Disorder (SAD) responding to 1 week of light therapy. METHOD: The response rate to 1-week light therapy and relapse during the continuation phase of 15 weeks were assessed by use of the Hamilton Depression Rating Scale (HAM-D17), the six-item subscale (HAM-D6), the Melancholia Scale (MES), and the combined HAM-D/SIGH-SAD. RESULTS: The response rate to light therapy was 62.5% on the HAM-D17 and the HAM-D6, 56.1% on the HAM-D/SIGH-SAD, 52.8% on the MES. In the continuation phase, citalopram was found superior to placebo on all scales, but the difference was only of statistical significance on the HAM-D6 and the MES. Mean citalopram dose was 26.3 mg. CONCLUSION:Light therapy was found to have and early onset of action. On the HAM-D6 and the MES citalopram significantly reduced the relapse rate in the continuation phase.
RCT Entities:
OBJECTIVE: We have tested the relapse-preventive effect of citalopram when compared with placebo in 282 patients with Seasonal Affective Disorder (SAD) responding to 1 week of light therapy. METHOD: The response rate to 1-week light therapy and relapse during the continuation phase of 15 weeks were assessed by use of the Hamilton Depression Rating Scale (HAM-D17), the six-item subscale (HAM-D6), the Melancholia Scale (MES), and the combined HAM-D/SIGH-SAD. RESULTS: The response rate to light therapy was 62.5% on the HAM-D17 and the HAM-D6, 56.1% on the HAM-D/SIGH-SAD, 52.8% on the MES. In the continuation phase, citalopram was found superior to placebo on all scales, but the difference was only of statistical significance on the HAM-D6 and the MES. Mean citalopram dose was 26.3 mg. CONCLUSION: Light therapy was found to have and early onset of action. On the HAM-D6 and the MES citalopram significantly reduced the relapse rate in the continuation phase.
Authors: Gerald Gartlehner; Barbara Nussbaumer-Streit; Bradley N Gaynes; Catherine A Forneris; Laura C Morgan; Amy Greenblatt; Jörg Wipplinger; Linda J Lux; Megan G Van Noord; Dietmar Winkler Journal: Cochrane Database Syst Rev Date: 2019-03-18
Authors: Chi-Un Pae; Prakash S Masand; Kathleen Peindl; Paolo Mannelli; Changsu Han; David M Marks; Ashwin A Patkar Journal: Prim Care Companion J Clin Psychiatry Date: 2008
Authors: Giovanni Camardese; Beniamino Leone; Riccardo Serrani; Coco Walstra; Marco Di Nicola; Giacomo Della Marca; Pietro Bria; Luigi Janiri Journal: Neuropsychiatr Dis Treat Date: 2015-09-09 Impact factor: 2.570