Literature DB >> 14981663

Recently synthesized class of vinylphosphonates as potent matrix metalloproteinase (MMP-2) inhibitors.

Abed Al-Aziz Al-Quntar1, Ofir Baum, Reuven Reich, Morris Srebnik.   

Abstract

An in vitro evaluation of MMP-2 inhibitors for a series of novel vinylphosphonic acids and phosphonic esters that contain various functional groups, shows that various types exhibit excellent efficiency, and points towards potent, promising compounds. Other types displayed relatively weak activity.

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Year:  2004        PMID: 14981663     DOI: 10.1002/ardp.200300828

Source DB:  PubMed          Journal:  Arch Pharm (Weinheim)        ISSN: 0365-6233            Impact factor:   3.751


  2 in total

1.  Theoretical studies on the Mo-catalyzed asymmetric intramolecular Pauson-Khand-type [2+2+1] cycloadditions of 3-allyloxy-1-propynylphosphonates.

Authors:  Qingxi Meng; Ming Li
Journal:  J Mol Model       Date:  2012-08       Impact factor: 1.810

2.  A QSAR Study of Matrix Metalloproteinases Type 2 (MMP-2) Inhibitors with Cinnamoyl Pyrrolidine Derivatives.

Authors:  Eduardo Borges de Melo
Journal:  Sci Pharm       Date:  2012-01-31
  2 in total

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