Karen L Koscica1, Georges Sylvestre, Sandra E Reznik. 1. Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.
Abstract
OBJECTIVE: Several metallopeptidases have been implicated in both term and preterm parturition. We hypothesize that endotoxin-induced preterm delivery can be prevented by the administration of a metallopeptidase inhibitor. STUDY DESIGN: We used an animal model of endotoxin-induced preterm delivery in timed pregnancy C57Bl/6 mice. Test animals received lipopolysaccharide followed by phosphoramidon, either every 1.5 or every 3 hours. Control mice received lipopolysaccharide followed by buffer injections at the same intervals. The primary outcome was a preterm delivery rate. RESULTS: The rate of preterm delivery for the control animals was 88.0% compared with the treatment groups of 45.5% for the mice that received phosphoramidon every 3 hours and 30.8% for the group that received it every 1.5 hours (P<.01). CONCLUSION: The administration of a metallopeptidase inhibitor resulted in a decreased rate of preterm delivery in this animal model.
OBJECTIVE: Several metallopeptidases have been implicated in both term and preterm parturition. We hypothesize that endotoxin-induced preterm delivery can be prevented by the administration of a metallopeptidase inhibitor. STUDY DESIGN: We used an animal model of endotoxin-induced preterm delivery in timed pregnancy C57Bl/6 mice. Test animals received lipopolysaccharide followed by phosphoramidon, either every 1.5 or every 3 hours. Control mice received lipopolysaccharide followed by buffer injections at the same intervals. The primary outcome was a preterm delivery rate. RESULTS: The rate of preterm delivery for the control animals was 88.0% compared with the treatment groups of 45.5% for the mice that received phosphoramidon every 3 hours and 30.8% for the group that received it every 1.5 hours (P<.01). CONCLUSION: The administration of a metallopeptidase inhibitor resulted in a decreased rate of preterm delivery in this animal model.
Authors: Sruthi Sundaram; Charles R Ashby; Ryan Pekson; Vaishali Sampat; Ravikumar Sitapara; Lin Mantell; Chih-Hung Chen; Haoting Yen; Khushboo Abhichandani; Swapna Munnangi; Nikhil Khadtare; Ralph A Stephani; Sandra E Reznik Journal: Am J Pathol Date: 2013-06-12 Impact factor: 4.307