OBJECTIVE: We studied the effect of labor on maternal neutrophil phenotype. STUDY DESIGN: Neutrophil apoptosis with inflammatory cytokines and the expression of CD11b, CD34 and toll-like receptor 4 (TLR4) were assessed with flow cytometry in women at uncomplicated vaginal delivery (VD), and elective cesarean section (ElCS) without labor, emergency cesarean section with (EmCSL+) or without (EmCSL-) labor. RESULTS: Spontaneous neutrophil apoptosis is delayed in maternal neutrophils after VD, EmCSL+ or EmCSL- versus ElCS. In all groups lipopolysaccharide delayed apoptosis and increased CD11b expression. Elevated TLR4 expression in ElCS was associated with lipopolysaccharide responsiveness. CD34 was diminished in VD, indicating increased cell maturity. CONCLUSION: Normal labor primes the neutrophil and may enhance antibacterial function by inducing a mild maternal inflammatory response syndrome. Delayed neutrophil apoptosis may promote the neutrophilia seen in women after VD. We suggest that labor of any duration may be immunologically beneficial to the parturient.
OBJECTIVE: We studied the effect of labor on maternal neutrophil phenotype. STUDY DESIGN: Neutrophil apoptosis with inflammatory cytokines and the expression of CD11b, CD34 and toll-like receptor 4 (TLR4) were assessed with flow cytometry in women at uncomplicated vaginal delivery (VD), and elective cesarean section (ElCS) without labor, emergency cesarean section with (EmCSL+) or without (EmCSL-) labor. RESULTS: Spontaneous neutrophil apoptosis is delayed in maternal neutrophils after VD, EmCSL+ or EmCSL- versus ElCS. In all groups lipopolysaccharide delayed apoptosis and increased CD11b expression. Elevated TLR4 expression in ElCS was associated with lipopolysaccharide responsiveness. CD34 was diminished in VD, indicating increased cell maturity. CONCLUSION: Normal labor primes the neutrophil and may enhance antibacterial function by inducing a mild maternal inflammatory response syndrome. Delayed neutrophil apoptosis may promote the neutrophilia seen in women after VD. We suggest that labor of any duration may be immunologically beneficial to the parturient.
Authors: Brett C Young; Aleksandar K Stanic; Britta Panda; Bo R Rueda; Alexander Panda Journal: Am J Obstet Gynecol Date: 2013-11-28 Impact factor: 8.661
Authors: H O Eliwan; R W G Watson; S Aslam; I Regan; B Philbin; F M O'Hare; A O'Neill; R Preston; A Blanco; T Grant; B Nolan; O Smith; E J Molloy Journal: Clin Exp Immunol Date: 2015-03 Impact factor: 4.330
Authors: Marit Stockfelt; Gunilla Larsson; Hanna Engström; Henri Puttonen; Henrik Zetterberg; Kaj Blennow; Christopher Sjöwall; Helena Strevens; Andreas Jönsen; Anders A Bengtsson; Maria Majczuk Sennström; Agneta Zickert; Elisabet Svenungsson; Iva Gunnarsson; Estelle Trysberg; Bo Jacobsson; Anna-Karin Hultgård Ekwall; Karin Christenson; Johan Bylund; Mattias N D Svensson; Anna-Carin Lundell Journal: Lupus Sci Med Date: 2021-03