| Literature DB >> 14980694 |
Xiang Y Yu1, John Finn, Jason M Hill, Zhong G Wang, Dennis Keith, Jared Silverman, N Oliver.
Abstract
We have identified a series of spirocyclic furan and pyrrolidine inhibitors of Enterococcus faecalis and Staphylococcus aureus phenylalanyl-tRNA synthetases. The most potent analogue 1b showed IC50=5 nM (E. faecalis PheRS) and IC50=2 nM (S. aureus PheRS) with high selectivity over the human enzyme. The crystal X-ray structure of analogue 1b was determined.Entities:
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Year: 2004 PMID： 14980694 DOI： 10.1016/j.bmcl.2003.11.081
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823