Literature DB >> 14980692

Anti-AIDS agents. Part 57: Actein, an anti-HIV principle from the rhizome of Cimicifuga racemosa (black cohosh), and the anti-HIV activity of related saponins.

Nobuko Sakurai1, Jiu-Hong Wu, Yutaka Sashida, Yoshihiro Mimaki, Tamotsu Nikaido, Kazuo Koike, Hideji Itokawa, Kuo-Hsiung Lee.   

Abstract

Actein (1), a tetracyclic triterpenoid from the rhizome of Cimicifuga racemosa (black cohosh), and 82 related triterpenoid and steroidal saponins isolated from higher plants were evaluated for anti-HIV activity as a continuing study to discover potential anti-AIDS agents from natural products. Actein showed potent activity and another twelve saponins showed moderate activity. The active compounds included two steroidal, seven tetracyclic triterpenoid, and four pentacyclic triterpenoid compounds.

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Year:  2004        PMID： 14980692     DOI： 10.1016/j.bmcl.2003.12.035

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  14 in total

Review 1.  Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach.

Authors:  Kuo-Hsiung Lee
Journal:  J Nat Prod       Date:  2010-03-26       Impact factor: 4.050

2.  Metabolic profiling of Actaea species extracts using high performance liquid chromatography coupled with electrospray ionization time-of-flight mass spectrometry.

Authors:  Chunhui Ma; Adam R Kavalier; Bei Jiang; Edward J Kennelly
Journal:  J Chromatogr A       Date:  2011-01-19       Impact factor: 4.759

Review 3.  Ethnobotany, Phytochemistry, Traditional and Modern Uses of Actaea racemosa L. (Black cohosh): A Review.

Authors:  Sofia Salari; Mohammad Sadegh Amiri; Mahin Ramezani; Ali Tafazoli Moghadam; Sepideh Elyasi; Amirhossein Sahebkar; Seyed Ahmad Emami
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

4.  In Vitro Cytotoxicity and Anti-HIV Activity of Crude Extracts of Croton macrostachyus, Croton megalocarpus and Croton dichogamus.

Authors:  Ermias Mergia Terefe; Faith Apolot Okalebo; Solomon Derese; Joseph Muriuki; Gaber El-Saber Batiha
Journal:  J Exp Pharmacol       Date:  2021-12-22

5.  Discovery and synthesis of novel beesioside I derivatives with potent anti-HIV activity.

Authors:  Haifeng Wu; Guoxu Ma; Qinwen Yang; Yindi Zhu; Li Huang; Yu Tian; Xiaoming Yang; Menghan Zhang; Chin-Ho Chen; Susan L Morris-Natschke; Meihua Yang; Xudong Xu; Kuo-Hsiung Lee
Journal:  Eur J Med Chem       Date:  2019-01-10       Impact factor: 6.514

6.  Chlorination diversifies Cimicifuga racemosa triterpene glycosides.

Authors:  Shao-Nong Chen; David C Lankin; Dejan Nikolic; Daniel S Fabricant; Zhi-Zhen Lu; Benjamin Ramirez; Richard B van Breemen; Harry H S Fong; Norman R Farnsworth; Guido F Pauli
Journal:  J Nat Prod       Date:  2007-06-08       Impact factor: 4.050

7.  Pharmacokinetics of 23-epi-26-deoxyactein in women after oral administration of a standardized extract of black cohosh.

Authors:  R B van Breemen; W Liang; S Banuvar; L P Shulman; Y Pang; Y Tao; D Nikolic; K M Krock; D S Fabricant; S-N Chen; S Hedayat; J L Bolton; G F Pauli; C E Piersen; E C Krause; S E Geller; N R Farnsworth
Journal:  Clin Pharmacol Ther       Date:  2009-12-23       Impact factor: 6.875

Review 8.  The potential of plant systems to break the HIV-TB link.

Authors:  Peyman Habibi; Henry Daniell; Carlos Ricardo Soccol; Maria Fatima Grossi-de-Sa
Journal:  Plant Biotechnol J       Date:  2019-07-18       Impact factor: 9.803

9.  New anti-angiogenic leading structure discovered in the fruit of Cimicifuga yunnanensis.

Authors:  Yin Nian; Jing Yang; Tong-Yang Liu; Ying Luo; Ji-Hong Zhang; Ming-Hua Qiu
Journal:  Sci Rep       Date:  2015-03-12       Impact factor: 4.379

Review 10.  Natural Products as Anti-HIV Agents and Role in HIV-Associated Neurocognitive Disorders (HAND): A Brief Overview.

Authors:  Kesava Rao V Kurapati; Venkata S Atluri; Thangavel Samikkannu; Gabriella Garcia; Madhavan P N Nair
Journal:  Front Microbiol       Date:  2016-01-12       Impact factor: 5.640
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