| Literature DB >> 14980686 |
John D Buynak1, Hansong Chen, Lakshminaryana Vogeti, Venkat Rao Gadhachanda, Christine A Buchanan, Timothy Palzkill, Robert W Shaw, James Spencer, Timothy R Walsh.
Abstract
The synthesis and beta-lactamase inhibitory activity of four 6-(mercaptomethyl)penicillinates and the four corresponding 6-(hydroxymethyl)penicillinates are described. These penicillins include both C6 stereoisomers as well as the sulfide and sulfone oxidation states of the penam thiazolidine sulfur. All compounds were evaluated as inhibitors of representative metallo- and serine-beta-lactamases enzymes. Selected (mercaptomethyl)penicillinates are shown to inactivate both metallo- and serine-beta-lactamases and to display synergism with piperacillin against beta-lactamase producing strains.Entities:
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Year: 2004 PMID： 14980686 DOI： 10.1016/j.bmcl.2003.12.037
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823